SRM Institute of Science and Technology, Delhi-NCR campus, Modinagar, India.
SRM Institute of Science and Technology, Delhi-NCR campus, Modinagar, India.
Int J Biol Macromol. 2020 Oct 1;160:489-495. doi: 10.1016/j.ijbiomac.2020.05.221. Epub 2020 May 29.
Hydrogel finds an interesting candidate in the biomedical field due to their unique properties such as biocompatibility, biodegradability, soft as tissue etc. In the reported research article natural biopolymer i.e. chitosan based hydrogel was developed via condensation reaction with cuminaldehyde. Chitosan and cuminaldehyde were used for the gel formation by covalent bonding between free amino group and carbonyl group of chitosan & cuminaldehyde respectively. A series of hydrogel has been developed by taking different concentration of cuminaldehyde (6-10 mmol). Chemical structure of the synthesized hydrogel was further confirmed by FTIR. The surface morphology of the synthesized hydrogel was confirmed from the scanning electron microscopy (SEM). Prepared hydrogel was swelled very fast similar to the super-porous hydrogel along with rapid self-healing property which is confirmed by rheology statistics. Mechanical strength of the hydrogel was investigated from the rheology analysis and demonstrates good mechanical properties i.e. storage modulus (G') found to 10 pa. Further, the sustained release of hydrophilic drug i.e. levofloxacin from the hydrogel matrix at different pH range 6-7 has been carried out. Hydrogel with maximum cuminaldehyde amount releases max drug i.e. 96% while hydrogel with 6 mmol shows minimum drug release i.e.54%. Hydrogel shows controlled release of levofloxacin up to 90 h. The present research work revealed that produced hydrogel will become a promising candidate in biomedical field.
水凝胶由于其独特的性能，如生物相容性、生物可降解性、柔软如组织等，在生物医学领域找到了一个有趣的候选者。在报道的研究文章中，天然生物聚合物，即壳聚糖基水凝胶，是通过与肉桂醛的缩合反应开发的。壳聚糖和肉桂醛通过壳聚糖和肉桂醛的游离氨基和羰基之间的共价键分别用于凝胶形成。通过使用不同浓度的肉桂醛（6-10 mmol）开发了一系列水凝胶。通过傅里叶变换红外光谱（FTIR）进一步确认了合成水凝胶的化学结构。通过扫描电子显微镜（SEM）确认了合成水凝胶的表面形态。所制备的水凝胶具有非常快速的溶胀性，类似于超多孔水凝胶，同时具有快速自修复性能，这通过流变学统计得到了证实。通过流变学分析研究了水凝胶的机械强度，并表现出良好的机械性能，即存储模量（G'）发现为 10 pa。进一步，在不同的 pH 值范围 6-7 下，从水凝胶基质中进行了亲水性药物左氧氟沙星的持续释放。含肉桂醛最多的水凝胶释放最多的药物，即 96%，而含 6 mmol 肉桂醛的水凝胶释放最少的药物，即 54%。水凝胶显示出长达 90 小时的左氧氟沙星的控制释放。本研究工作表明，所制备的水凝胶将成为生物医学领域有前途的候选者。
