Department of Biological Sciences, Vanderbilt University, Nashville, TN, United States.
Curr Opin Cell Biol. 2019 Aug;59:8-15. doi: 10.1016/j.ceb.2019.02.004. Epub 2019 Mar 18.
Molecular mechanisms underlying the formation of multiple classes of transport carriers or vesicles from Golgi and endosomal membranes remain poorly understood. However, one theme that has emerged over three decades is the dramatic influence of membrane lipid remodeling on transport mechanisms. A large cohort of lipid transfer proteins, lipid transporters, and lipid modifying enzymes are linked to protein sorting, carrier formation and SNARE-mediated fusion events. Here, we focus on one type of lipid transporter, phospholipid flippases in the type IV P-type ATPase (P4-ATPase) family, and discuss recent advances in defining P4-ATPase influences on membrane remodeling and vesicular transport.
高尔基体和内体膜形成多种运输载体或囊泡的分子机制仍知之甚少。然而，三十多年来出现的一个主题是膜脂重塑对运输机制的巨大影响。一大群脂质转移蛋白、脂质转运体和脂质修饰酶与蛋白质分拣、载体形成和 SNARE 介导的融合事件有关。在这里，我们专注于一种脂质转运体，即 IV 型 P 型 ATP 酶（P4-ATPase）家族中的磷脂翻转酶，并讨论了最近在定义 P4-ATPase 对膜重塑和囊泡运输的影响方面的进展。
