Traa Willeke A, van Turnhout Mark C, Nelissen Jules L, Strijkers Gustav J, Bader Dan L, Oomens Cees W J
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Clin Biomech (Bristol). 2019 Mar;63:153-160. doi: 10.1016/j.clinbiomech.2019.02.015. Epub 2019 Feb 23.
Deep tissue injury is a type of pressure ulcer which originates subcutaneously due to sustained mechanical loading. The relationship between mechanical compression and damage development has been extensively studied in 2D. However, recent studies have suggested that damage develops beyond the site of indentation. The objective of this study was to compare mechanical loading conditions to the associated damage in 3D.
An indentation test was performed on the tibialis anterior muscle of rats (n = 39). Changes in the form of oedema and structural damage were monitored with MRI in an extensive region. The internal deformations were evaluated using MRI based 3D finite element models.
Damage propagates away from the loaded region. The 3D analysis indicates that there is a subject specific tolerance to compression induced deep tissue injury.
Individual tolerance is an important factor when considering the mechanical loading conditions which induce damage.
深部组织损伤是一种因持续机械负荷而起源于皮下的压疮类型。机械压缩与损伤发展之间的关系已在二维层面进行了广泛研究。然而，近期研究表明损伤会在压痕部位以外发展。本研究的目的是比较三维情况下的机械负荷条件与相关损伤情况。
对大鼠（n = 39）的胫骨前肌进行压痕试验。在一个广泛区域内用磁共振成像（MRI）监测水肿形式和结构损伤的变化。使用基于MRI的三维有限元模型评估内部变形情况。
损伤从加载区域向外扩展。三维分析表明，对于压缩诱导的深部组织损伤存在个体特异性耐受性。
在考虑诱导损伤的机械负荷条件时，个体耐受性是一个重要因素。
