State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, PR China; University of the Chinese Academy of Sciences, Beijing 100049, PR China.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, PR China; University of the Chinese Academy of Sciences, Beijing 100049, PR China.
Biosens Bioelectron. 2019 May 1;132:333-342. doi: 10.1016/j.bios.2019.01.046. Epub 2019 Jan 29.
Fluorescent copper nanomaterials (CuNMs), including copper nanoparticles (CuNPs) and copper nanoclusters (CuNCs), become more and more popular with the abundant raw materials and low cost. A wide range of applications has been explored due to their fascinating properties such as low toxicity, remarkable water solubility, facile synthesis, large Stokes shifts, and good biocompatibility. As a kind of genetic material, DNA exhibits its molecular recognition function and diversity. The marriage between CuNMs and DNA endows DNA-templated CuNMs (DNA-CuNMs) with unique properties such as fluorescence, electrochemiluminescence and catalytic features. In this review, we summarize the synthesis and recent applications of DNA-CuNMs. Fluorescent CuNMs can be grown on various DNA scaffolds with special sequence design. T base plays an important role in the formation of CuNMs on DNA templates. These fluorescent DNA-CuNMs hold great prospect in logic gate construction, staining and biosensing of DNAs and RNAs, ions, proteins and enzymes, small molecules and so on.
荧光铜纳米材料（CuNMs），包括铜纳米粒子（CuNPs）和铜纳米团簇（CuNCs），由于其丰富的原料和低成本而变得越来越受欢迎。由于其具有低毒性、显著的水溶性、易于合成、大斯托克斯位移和良好的生物相容性等迷人特性，因此已经探索了广泛的应用。作为一种遗传物质，DNA 表现出其分子识别功能和多样性。CuNMs 与 DNA 的结合赋予了 DNA 模板铜纳米材料（DNA-CuNMs）独特的性质，如荧光、电化学发光和催化特性。在这篇综述中，我们总结了 DNA-CuNMs 的合成和最新应用。荧光 CuNMs 可以在具有特殊序列设计的各种 DNA 支架上生长。T 碱基在 DNA 模板上形成 CuNMs 中起着重要作用。这些荧光 DNA-CuNMs 在逻辑门构建、DNA 和 RNA、离子、蛋白质和酶、小分子等的染色和生物传感方面具有广阔的前景。
