Rył Aleksandra, Rotter Iwona, Miazgowski Tomasz, Słojewski Marcin, Dołęgowska Barbara, Lubkowska Anna, Laszczyńska Maria
Chair and Department of Histology and Developmental Biology, Pomeranian Medical University, Szczecin, Poland.
Department of Medical Rehabilitation, Pomeranian Medical University, Szczecin, Poland.
Diabetol Metab Syndr. 2015 Oct 29;7:94. doi: 10.1186/s13098-015-0089-1. eCollection 2015.
It has been suggested that individuals with metabolic syndrome (MetS) may be prone to developing benign prostatic hyperplasia (BPH), but the direction of causality remains uncertain. The objective of this cross-sectional study was to evaluate the association between BPH and MetS in men who were referred to surgery for BPH. We were interested in identifying the anthropometric, metabolic, and hormonal factors that potentially influence the risk of both conditions.
The study was conducted on 128 males with BPH and 141 without BPH (the control group). Fasting glucose, insulin, lipid profiles, total and free testosterone, estradiol, sex-hormone binding protein (SHBG), dehydroepiandrosterone sulfate (DHEA-S), homeostasis model assessment (HOMA-IR) index, and lipid accumulation product (LAP) were all evaluated.
The prevalence of MetS was higher in patients with BPH than in the controls (58 vs. 41 %; P = 0.007). In comparison to the controls, patients with BPH had higher levels of cholesterol, low density lipoproteins, DHEA-S, insulin, and HOMA-IR, but lower levels of high-density lipoproteins (HDL), estradiol, and SHBG. The significant predictors of BPH were MetS (OR = 1.961), age (OR = 0.11), HDL (OR = 0.91), insulin (OR = 1.224), SHBG (OR = 0.98), and estradiol (OR = 0.978). Waist circumference and LAP inversely correlated with total and free testosterone and SHBG.
Our study confirmed the frequent coexistence of MetS and BPH. This association seems to be a consequence of the MetS-related metabolic derangements, changes in the sex-hormone milieu, and lowered SHBG levels.
有研究表明，患有代谢综合征（MetS）的个体可能更容易患上良性前列腺增生（BPH），但因果关系的方向仍不确定。这项横断面研究的目的是评估因BPH接受手术治疗的男性中BPH与MetS之间的关联。我们感兴趣的是确定可能影响这两种疾病风险的人体测量、代谢和激素因素。
对128例BPH男性患者和141例无BPH男性患者（对照组）进行了研究。评估了空腹血糖、胰岛素、血脂谱、总睾酮和游离睾酮、雌二醇、性激素结合蛋白（SHBG）、硫酸脱氢表雄酮（DHEA-S）、稳态模型评估（HOMA-IR）指数和脂质积聚产物（LAP）。
BPH患者中MetS的患病率高于对照组（58%对41%；P = 0.007）。与对照组相比，BPH患者的胆固醇、低密度脂蛋白、DHEA-S、胰岛素和HOMA-IR水平较高，但高密度脂蛋白（HDL）、雌二醇和SHBG水平较低。BPH的显著预测因素是MetS（OR = 1.961）、年龄（OR = 0.11）、HDL（OR = 0.91）、胰岛素（OR = 1.224）、SHBG（OR = 0.98）和雌二醇（OR = 0.978）。腰围和LAP与总睾酮、游离睾酮和SHBG呈负相关。
我们的研究证实了MetS和BPH经常共存。这种关联似乎是MetS相关代谢紊乱、性激素环境变化和SHBG水平降低的结果。
