The Key Laboratory of Pathobiology, Ministry of Education, Norman Bethune College of Medicine, Jilin University, 126 Xinmin Street, Changchun, Jilin, 130021, People's Republic of China.
Stem Cell Res Ther. 2019 Mar 21;10(1):103. doi: 10.1186/s13287-019-1186-0.
In addition to its primary function to provide movement and maintain posture, the skeletal muscle plays important roles in energy and glucose metabolism. In healthy humans, skeletal muscle is the major site for postprandial glucose uptake and impairment of this process contributes to the pathogenesis of type 2 diabetes mellitus (T2DM). A key component to the maintenance of skeletal muscle integrity and plasticity is the presence of muscle progenitor cells, including satellite cells, fibroadipogenic progenitors, and some interstitial progenitor cells associated with vessels (myo-endothelial cells, pericytes, and mesoangioblasts). In this review, we aim to discuss the emerging concepts related to these progenitor cells, focusing on the identification and characterization of distinct progenitor cell populations, and the impact of obesity and T2DM on these cells. The recent advances in stem cell therapies by targeting diabetic and obese muscle are also discussed.
除了提供运动和维持姿势的主要功能外，骨骼肌在能量和葡萄糖代谢中也起着重要作用。在健康的人类中，骨骼肌是餐后葡萄糖摄取的主要部位，而这一过程的受损导致了 2 型糖尿病（T2DM）的发病机制。维持骨骼肌完整性和可塑性的关键组成部分是存在肌肉祖细胞，包括卫星细胞、纤维脂肪生成祖细胞和一些与血管相关的间充质祖细胞（肌内皮细胞、周细胞和中胚层祖细胞）。在这篇综述中，我们旨在讨论与这些祖细胞相关的新兴概念，重点是鉴定和描述不同的祖细胞群体，以及肥胖和 T2DM 对这些细胞的影响。还讨论了针对糖尿病和肥胖肌肉的干细胞治疗的最新进展。
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