Matias Caio M, Sharan Ashwini, Wu Chengyuan
Department of Neurological Surgery, Thomas Jefferson University Hospitals, Philadelphia, PA, USA; Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Department of Neurological Surgery, Thomas Jefferson University Hospitals, Philadelphia, PA, USA.
Neurosurg Clin N Am. 2019 Apr;30(2):231-242. doi: 10.1016/j.nec.2018.12.006. Epub 2019 Feb 18.
There are a significant number of patients with epilepsy who are drug-resistant and for whom resective procedures are not an option. For these patients, neuromodulation may be an option, including closed-loop stimulation, such as responsive neurostimulation (RNS). The RNS System is a programmable and responsive device that consists of leads, a pulse generator, and an external programmer. An algorithm detects specific patterns of epileptogenic activity and triggers focal stimulation to interrupt a seizure. RNS is an effective and safe adjunctive therapy that in addition to seizure frequency reduction may have other applications, such as drug-response evaluation and long-term electrocorticography recording.
有相当数量的癫痫患者对药物耐药，且不适合进行切除手术。对于这些患者，神经调节可能是一种选择，包括闭环刺激，如反应性神经刺激（RNS）。RNS系统是一种可编程的反应性设备，由电极导线、脉冲发生器和外部编程器组成。一种算法可检测致痫活动的特定模式，并触发局部刺激以中断癫痫发作。RNS是一种有效且安全的辅助治疗方法，除了降低癫痫发作频率外，可能还有其他应用，如药物反应评估和长期皮质脑电图记录。
