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一种用于动物研究的价格合理的植入式迷走神经刺激器系统。

An affordable implantable vagus nerve stimulator system for use in animal research.

作者信息

Canal-Alonso Ángel, Casado-Vara Roberto, Castellano Orlando, Herrera-Santos Jorge, Gonçalves Jaime, Màrquez-Sànchez Sergio, Gonçalves Jesús María, Corchado Juan Manuel

机构信息

Bioinformatics, Intelligent Systems and Educational Technology (BISITE) Research Group, Salamanca, Spain.

Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.

出版信息

Philos Trans A Math Phys Eng Sci. 2022 Jul 25;380(2228):20210010. doi: 10.1098/rsta.2021.0010. Epub 2022 Jun 6.

DOI:10.1098/rsta.2021.0010
PMID:35658680
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9168444/
Abstract

In this research, a vagus nerve stimulator has been developed and miniaturized for use in epilepsy research. The board contains all the components necessary for its operation during the standard duration of the experiments, being possible to control it once implanted and even being able to reuse it. The VNS system has been designed for rodents since the VNS devices available for human are not only too large for laboratory animals, but also too expensive. With this solution the expenditure on materials made by laboratories is greatly reduced and bioethical considerations were kept in mind. The system was validated in hamsters. This article is part of the theme issue 'Advanced neurotechnologies: translating innovation for health and well-being'.

摘要

在本研究中，已开发出一种用于癫痫研究的小型化迷走神经刺激器。该电路板包含实验标准时长内运行所需的所有组件，植入后即可对其进行控制，甚至能够重复使用。由于现有的用于人类的迷走神经刺激设备不仅对实验动物来说太大，而且太贵，因此该迷走神经刺激系统是专为啮齿动物设计的。通过这种解决方案，实验室的材料支出大幅减少，同时也考虑到了生物伦理因素。该系统在仓鼠身上得到了验证。本文是主题为“先进神经技术：将创新转化为健康与福祉”的一部分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf4/9168444/63e4d16e40c8/rsta20210010f07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf4/9168444/017c0899efd8/rsta20210010f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf4/9168444/03f860cffaa1/rsta20210010f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf4/9168444/9f732bc30953/rsta20210010f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf4/9168444/8b3e8aa6f324/rsta20210010f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf4/9168444/8ab4fc2c95b2/rsta20210010f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf4/9168444/b17e663581c0/rsta20210010f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf4/9168444/63e4d16e40c8/rsta20210010f07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf4/9168444/017c0899efd8/rsta20210010f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf4/9168444/03f860cffaa1/rsta20210010f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf4/9168444/9f732bc30953/rsta20210010f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf4/9168444/8b3e8aa6f324/rsta20210010f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf4/9168444/8ab4fc2c95b2/rsta20210010f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf4/9168444/b17e663581c0/rsta20210010f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1cf4/9168444/63e4d16e40c8/rsta20210010f07.jpg

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Epilepsy Behav. 2021 Apr;117:107868. doi: 10.1016/j.yebeh.2021.107868. Epub 2021 Mar 5.
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Transcranial direct current stimulation (tDCS) in the management of epilepsy: A systematic review.经颅直流电刺激（tDCS）在癫痫管理中的应用：系统评价。
Seizure. 2021 Mar;86:85-95. doi: 10.1016/j.seizure.2021.01.020. Epub 2021 Feb 5.
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Learnings from 30 years of reported efficacy and safety of vagus nerve stimulation (VNS) for epilepsy treatment: A critical review.
Philos Trans A Math Phys Eng Sci. 2022 Jul 25;380(2228):20210004. doi: 10.1098/rsta.2021.0004. Epub 2022 Jun 6.
30 年来迷走神经刺激（VNS）治疗癫痫疗效和安全性报告的经验教训：批判性回顾。
Seizure. 2020 Dec;83:104-123. doi: 10.1016/j.seizure.2020.09.027. Epub 2020 Oct 10.
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The RNS System: brain-responsive neurostimulation for the treatment of epilepsy.RNS 系统：用于治疗癫痫的脑反应神经刺激。
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