O'Shea G M, Sun A M
Diabetes. 1986 Aug;35(8):943-6. doi: 10.2337/diab.35.8.943.
Rat islets encapsulated in alginate-polylysine membranes were implanted intraperitoneally into nonimmunosuppressed streptozocin-induced diabetic mice. Diabetes was reversed within 3 days, and the animals remained normoglycemic for up to 144 days, with a mean xenograft survival of 80 days. This was significantly greater than nonencapsulated islets, which functioned for less than 14 days. The graft survival rate at 50 days was greater than 80%. Xenografts of rat islets encapsulated in alginate-polyornithine membranes also had a prolonged survival rate. This study demonstrates that encapsulation of pancreatic islets in semipermeable membranes can prolong xenograft survival in the absence of immunosuppression.
将包裹在藻酸盐-聚赖氨酸膜中的大鼠胰岛经腹腔植入未进行免疫抑制的链脲佐菌素诱导的糖尿病小鼠体内。糖尿病在3天内得到逆转，这些动物血糖正常长达144天，异种移植物平均存活80天。这显著长于未包裹的胰岛，后者的功能维持不到14天。50天时移植物存活率大于80%。包裹在藻酸盐-聚鸟氨酸膜中的大鼠胰岛异种移植物也有延长的存活率。本研究表明，在半透膜中包裹胰岛可在无免疫抑制的情况下延长异种移植物的存活时间。
