Peeters M, Vanden Berghe D, Meheus A
Genitourin Med. 1986 Jun;62(3):163-5. doi: 10.1136/sti.62.3.163.
The in vitro activity of seven metallic compounds was tested against penicillinase (beta lactamase) producing strains of Neisseria gonorrhoeae (PPNG) and non-PPNG strains. On a weight basis, the mercurials showed the greatest in vitro activity. Phenylmercuric borate, thiomersal, and mercuric chloride inhibited 90% of all strains at concentrations of 5 mg/l, 5 mg/l, and 20 mg/l respectively. Silver nitrate inhibited 90% of the strains at 80 mg/l and the MIC90 for mild silver protein was 200 mg/l. Copper and selenium salts had lower in vitro activities, inhibiting 90% of all the strains at 320 mg/l and 640 mg/l respectively. Silver nitrate and the six other compounds tested showed equal activities against PPNG and non-PPNG strains. This finding supports the recommendation for prophylaxis of gonococcal conjunctivitis of the newborn with 1% silver nitrate eye drops.
测试了七种金属化合物对产青霉素酶（β-内酰胺酶）的淋病奈瑟菌（PPNG）菌株和非PPNG菌株的体外活性。以重量计，汞化合物显示出最大的体外活性。苯基硼酸汞、硫柳汞和氯化汞分别在浓度为5mg/l、5mg/l和20mg/l时抑制了所有菌株的90%。硝酸银在80mg/l时抑制了90%的菌株，轻度银蛋白的MIC90为200mg/l。铜盐和硒盐的体外活性较低，分别在320mg/l和640mg/l时抑制了所有菌株的90%。硝酸银和其他六种测试化合物对PPNG和非PPNG菌株显示出相同的活性。这一发现支持了用1%硝酸银滴眼液预防新生儿淋菌性结膜炎的建议。
