Fransen L, Nsanze H, D'Costa L, Brunham R C, Ronald A R, Piot P
Lancet. 1984 Dec 1;2(8414):1234-7. doi: 10.1016/s0140-6736(84)92794-6.
117 infants with gonococcal ophthalmia neonatorum, including 27 with infections due to penicillinase-producing Neisseria gonorrhoeae, were treated as outpatients with five different regimens of single-dose intramuscular kanamycin (75 mg or 150 mg) with saline eye washes, gentamicin eye ointment, or chloramphenicol eye drops. There were no treatment failures among 68 patients treated with 75 mg or 150 mg kanamycin and gentamicin eye ointment (for 3 days). However, the minimum and maximum cumulative probabilities of cure of single-dose kanamycin with saline eye washes (for 3 days) were only 60% and 89%. 1 patient of 15 treated with 150 mg kanamycin plus chloramphenicol eye drops did not respond to treatment. Postgonococcal conjunctivitis developed in 14 (12%) infants, of whom 13 had positive cultures for Chlamydia trachomatis. Nasopharyngeal infection with N gonorrhoeae was eradicated in 9 of 11 infants colonised.
117例新生儿淋菌性眼炎患儿，其中27例感染由产青霉素酶的淋病奈瑟菌引起，作为门诊患者采用五种不同方案治疗，即单剂量肌内注射卡那霉素（75mg或150mg）加生理盐水洗眼、庆大霉素眼膏或氯霉素滴眼液。68例接受75mg或150mg卡那霉素及庆大霉素眼膏治疗（3天）的患者中无治疗失败病例。然而，单剂量卡那霉素加生理盐水洗眼（3天）治愈的最小和最大累积概率仅为60%和89%。15例接受150mg卡那霉素加氯霉素滴眼液治疗的患者中有1例治疗无反应。14例（12%）婴儿发生淋菌性结膜炎后结膜炎，其中13例沙眼衣原体培养阳性。11例定植的婴儿中有9例鼻咽部淋病奈瑟菌感染被根除。
