淋病奈瑟菌的抗菌敏感性。产青霉素酶菌株与非产青霉素酶菌株的比较。
Antimicrobial sensitivity of Neisseria gonorrhoeae. Comparison of penicillinase producing and non-penicillinase producing strains.
作者信息
Herzog C, Ison C A, Easmon C S
出版信息
Br J Vener Dis. 1983 Oct;59(5):289-92. doi: 10.1136/sti.59.5.289.
Abstract
The sensitivity of 42 strains of penicillinase producing Neisseria gonorrhoeae (PPNG) and 46 strains of non-PPNG was tested against benzyl penicillin, spectinomycin, erythromycin, cefuroxime, ceftriaxone, tetracycline, sulphamethoxazole, and trimethoprim. The minimum inhibitory concentrations (MICs) of all antimicrobials, except trimethoprim and ceftriaxone, differed significantly for PPNG and non-PPNG strains. Ceftriaxone was the most active compound tested, the MIC for all strains being less than or equal to 0.015 mg/1. PPNG were less sensitive than non-PPNG strains to spectinomycin. It remains to be seen whether the increase in prevalence of PPNG strains is followed by a gradual increase in low level resistance to spectinomycin as well as the occasional finding of high level resistance to this antibiotic.
摘要
对42株产青霉素酶淋病奈瑟菌（PPNG）和46株非PPNG菌株进行了针对苄青霉素、壮观霉素、红霉素、头孢呋辛、头孢曲松、四环素、磺胺甲恶唑和甲氧苄啶的敏感性测试。除甲氧苄啶和头孢曲松外，所有抗菌药物对PPNG和非PPNG菌株的最低抑菌浓度（MIC）差异显著。头孢曲松是测试中活性最强的化合物，所有菌株的MIC均小于或等于0.015mg/1。PPNG菌株对壮观霉素的敏感性低于非PPNG菌株。PPNG菌株患病率的增加是否会随之出现对壮观霉素低水平耐药性的逐渐增加以及偶尔出现对该抗生素的高水平耐药性，仍有待观察。
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