Heinonen P K, Teisala K, Punnonen R, Aine R, Lehtinen M, Miettinen A, Paavonen J
Genitourin Med. 1986 Aug;62(4):235-9. doi: 10.1136/sti.62.4.235.
The best way of treating pelvic inflammatory disease (PID) is not known. The clinical response to two treatment regimens (penicillin plus metronidazole v doxycycline plus metronidazole) was studied in 33 patients with PID confirmed by laparoscopy and endometrial biopsy. The overall failure rate, according to the criteria used in this study was five of 11 (45%) women with chlamydial PID, none of six women with gonococcal PID, all of four women with chlamydial gonococcal PID, and three (25%) of 12 women with non-chlamydial non-gonococcal PID. The failure rate with penicillin plus metronidazole treatment was unacceptably high (53%), and significantly higher than that with doxycycline plus metronidazole (19%) (p = 0.038). In most cases the microbiological and histopathological evaluations identified a probable explanation for the poor response to the treatment regimen used.
治疗盆腔炎（PID）的最佳方法尚不清楚。对33例经腹腔镜检查和子宫内膜活检确诊为PID的患者，研究了两种治疗方案（青霉素加甲硝唑与多西环素加甲硝唑）的临床反应。根据本研究使用的标准，总体失败率为：11例衣原体性PID女性中有5例（45%），6例淋菌性PID女性中无一例，4例衣原体淋菌混合性PID女性中全部，以及12例非衣原体非淋菌性PID女性中有3例（25%）。青霉素加甲硝唑治疗的失败率高得令人无法接受（53%），且显著高于多西环素加甲硝唑治疗的失败率（19%）（p = 0.038）。在大多数情况下，微生物学和组织病理学评估确定了对所用治疗方案反应不佳的可能原因。
