趋化因子介导的皮肤癌中免疫细胞迁移的来龙去脉。
The Ins and Outs of Chemokine-Mediated Immune Cell Trafficking in Skin Cancer.
机构信息
Immunology Division, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Faculty of Medicine, St Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.
出版信息
Front Immunol. 2019 Mar 7;10:386. doi: 10.3389/fimmu.2019.00386. eCollection 2019.
Abstract
Recent studies of the patterns of chemokine-mediated immune cell recruitment into solid tumors have enhanced our understanding of the role played by various immune cell subsets both in amplifying and inhibiting tumor cell growth and spread. Here we discuss how the chemokine/chemokine receptor networks bring together immune cells within the microenvironment of skin tumors, particularly melanomas, including their effect on disease progression, prognosis and therapeutic options.
摘要
最近对趋化因子介导的免疫细胞募集到实体瘤中的模式的研究，增强了我们对各种免疫细胞亚群在放大和抑制肿瘤细胞生长和扩散中所起作用的理解。在这里，我们讨论趋化因子/趋化因子受体网络如何将免疫细胞聚集在皮肤肿瘤（特别是黑色素瘤）的微环境中，包括它们对疾病进展、预后和治疗选择的影响。
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