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Diagnostic applications for Lassa fever in limited-resource settings.在资源有限的环境中用于拉沙热的诊断应用。
BMJ Glob Health. 2019 Feb 7;4(Suppl 2):e001119. doi: 10.1136/bmjgh-2018-001119. eCollection 2019.
2
Diagnostics for Lassa fever virus: a genetically diverse pathogen found in low-resource settings.拉沙热病毒的诊断：一种在资源匮乏地区发现的基因多样的病原体。
BMJ Glob Health. 2019 Feb 7;4(Suppl 2):e001116. doi: 10.1136/bmjgh-2018-001116. eCollection 2019.
3
Current research for a vaccine against Lassa hemorrhagic fever virus.目前针对拉沙出血热病毒疫苗的研究。
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Pathogenicity and virulence mechanisms of Lassa virus and its animal modeling, diagnostic, prophylactic, and therapeutic developments.拉沙病毒的致病性和毒力机制及其动物模型、诊断、预防和治疗的发展。
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Current sampling and sequencing biases of Lassa mammarenavirus limit inference from phylogeography and molecular epidemiology in Lassa fever endemic regions.拉沙哺乳类沙粒病毒目前的采样和测序偏差限制了对拉沙热流行地区系统地理学和分子流行病学的推断。
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本文引用的文献

1
Diagnostics for Lassa fever virus: a genetically diverse pathogen found in low-resource settings.拉沙热病毒的诊断：一种在资源匮乏地区发现的基因多样的病原体。
BMJ Glob Health. 2019 Feb 7;4(Suppl 2):e001116. doi: 10.1136/bmjgh-2018-001116. eCollection 2019.
2
The cascade of care following community-based detection of HIV in sub-Saharan Africa - A systematic review with 90-90-90 targets in sight.撒哈拉以南非洲社区为基础的 HIV 检测后护理的级联反应——一项有 90-90-90 目标的系统评价。
PLoS One. 2018 Jul 27;13(7):e0200737. doi: 10.1371/journal.pone.0200737. eCollection 2018.
3
The challenges of detecting and responding to a Lassa fever outbreak in an Ebola-affected setting.在埃博拉疫情影响下发现和应对拉沙热疫情的挑战。
Int J Infect Dis. 2018 Jan;66:65-73. doi: 10.1016/j.ijid.2017.11.007. Epub 2017 Nov 11.
4
A Case of Human Lassa Virus Infection With Robust Acute T-Cell Activation and Long-Term Virus-Specific T-Cell Responses.一例伴有强烈急性T细胞活化和长期病毒特异性T细胞反应的人拉沙病毒感染病例。
J Infect Dis. 2017 Jun 15;215(12):1862-1872. doi: 10.1093/infdis/jix201.
5
Laboratory Diagnosis of Lassa Fever.拉沙热的实验室诊断
J Clin Microbiol. 2017 Jun;55(6):1629-1637. doi: 10.1128/JCM.00170-17. Epub 2017 Apr 12.
6
Immunobiology of Ebola and Lassa virus infections.埃博拉病毒和拉萨热病毒感染的免疫生物学。
Nat Rev Immunol. 2017 Mar;17(3):195-207. doi: 10.1038/nri.2016.138. Epub 2017 Jan 23.
7
Molecular epidemiology of Crimean-Congo haemorrhagic fever virus in India.印度克里米亚-刚果出血热病毒的分子流行病学
Epidemiol Infect. 2016 Dec;144(16):3422-3425. doi: 10.1017/S0950268816001886. Epub 2016 Aug 15.
8
Time for a Model List of Essential Diagnostics.是时候列出一份基本诊断方法的模型清单了。
N Engl J Med. 2016 Jun 30;374(26):2511-4. doi: 10.1056/NEJMp1602825.
9
Vaccine platforms to control Lassa fever.用于控制拉沙热的疫苗平台。
Expert Rev Vaccines. 2016 Sep;15(9):1135-50. doi: 10.1080/14760584.2016.1184575. Epub 2016 May 24.
10
Expanding the role of diagnostic and prognostic tools for infectious diseases in resource-poor settings.扩大传染病诊断和预后工具在资源匮乏地区的作用。
Nature. 2015 Dec 3;528(7580):S50-2. doi: 10.1038/nature16038.

在资源有限的环境中用于拉沙热的诊断应用。

Diagnostic applications for Lassa fever in limited-resource settings.

作者信息

Emperador Devy M, Yimer Solomon A, Mazzola Laura T, Norheim Gunnstein, Kelly-Cirino Cassandra

机构信息

Foundation for Innovative New Diagnostics (FIND), Emerging Threats Programme, Geneva, Switzerland.

Department of Vaccine Science, Coalition for Epidemic Preparedness Innovation (CEPI), Oslo, Norway.

出版信息

BMJ Glob Health. 2019 Feb 7;4(Suppl 2):e001119. doi: 10.1136/bmjgh-2018-001119. eCollection 2019.

DOI:10.1136/bmjgh-2018-001119
PMID:30899576
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6407552/
Abstract

Lassa fever, caused by arenavirus Lassa virus (LASV), is an acute viral haemorrhagic disease that affects up to an estimated 300 000 individuals and causes up to 5000 deaths per year in West Africa. Currently available LASV diagnostic methods are difficult to operationalise in low-resource health centres and may be less sensitive to detecting all known or emerging LASV strains. To prioritise diagnostic development for LASV, we assessed the diagnostic applications for case detection, clinical management, surveillance, outbreak response, and therapeutic and vaccine development at various healthcare levels. Diagnostic development should prioritise point-of-care and near-patient diagnostics, especially those with the ability to detect all lineages of LASV, as they would allow for rapid detection in resource-limited health facilities closer to the patient.

摘要

拉沙热由沙粒病毒拉沙病毒（LASV）引起，是一种急性病毒性出血热疾病，在西非估计每年影响多达30万人，并导致多达5000人死亡。目前可用的拉沙病毒诊断方法在资源匮乏的卫生中心难以实施，并且在检测所有已知或新出现的拉沙病毒毒株方面可能不太敏感。为了优先开展拉沙病毒的诊断研发，我们评估了在各级医疗保健机构中用于病例检测、临床管理、监测、疫情应对以及治疗和疫苗研发的诊断应用。诊断研发应优先考虑即时检测和床旁检测，尤其是那些能够检测所有拉沙病毒谱系的检测方法，因为它们能够在更靠近患者的资源有限的卫生设施中实现快速检测。