营养不良婴儿的神经认知功能；与长链多不饱和脂肪酸、微量营养素水平及磁共振波谱的关系

Neurocognitive Functions in Infants with Malnutrition; Relation with Long-chain Polyunsaturated Fatty Acids, Micronutrients Levels and Magnetic Resonance Spectroscopy.

作者信息

Cakir Murat, Senyuva Sukran, Kul Sibel, Sag Elif, Cansu Ali, Yucesan Fulya Balaban, Yaman Serap Ozer, Orem Asim

机构信息

Department of Pediatric Gastroenterology Hepatology and Nutrition, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.

Department of Pediatrics, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.

出版信息

Pediatr Gastroenterol Hepatol Nutr. 2019 Mar;22(2):171-180. doi: 10.5223/pghn.2019.22.2.171. Epub 2019 Feb 27.

DOI:10.5223/pghn.2019.22.2.171

PMID:30899693

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6416383/

Abstract

PURPOSE

Malnutrition may influence neurocognitive development in children by directly affecting the brain structural development, or indirectly by affecting the children's cognition experience. Malnutrition alters the cell numbers, cell migration, synaptogenesis, and neurotransmission due to inadequate availability of necessary micronutrients to support cell growth. We aimed to analyze neurocognitive development in infants with malnutrition and its association with long chain polyunsaturated fatty acids (LC-PUFA), micronutrients levels and magnetic resonance spectroscopy (MRS) findings.

METHODS

The study included two groups; group 1, infants with malnutrition (n=24), group 2; healthy infants (n=21). Peripheral blood was obtained from the participants for studying micronutrients and LC-PUFA levels. The neurocognitive development was analyzed by the use of an Ankara Developmental Screening Inventory test. MRS were performed on all infants.

RESULTS

All parameters of neurocognitive development and serum calcium (9.6±0.9 mg/dL vs. 10.4±0.3 mg/dL, <0.05) and magnesium (2.02±0.27 mg/dL vs. 2.2±0.14 mg/dL, <0.05) levels were noted as being low in infants with marked malnutrition. No difference was found in LC-PUFA levels between healthy and malnourished infants. Thalamic choline/creatine levels were significantly high in infants with malnutrition (1.33±0.22 vs. 1.18±0.22, <0.05). Total neurocognitive development in infants was positively correlated with serum calcium levels (<0.05, r=0.381).

CONCLUSION

Calcium supplementation may improve neurocognitive development in malnourished infants.

摘要

目的

营养不良可能通过直接影响脑结构发育或间接影响儿童认知体验来影响儿童的神经认知发育。由于支持细胞生长的必需微量营养素供应不足，营养不良会改变细胞数量、细胞迁移、突触形成和神经传递。我们旨在分析营养不良婴儿的神经认知发育及其与长链多不饱和脂肪酸（LC-PUFA）、微量营养素水平和磁共振波谱（MRS）结果的关联。

方法

该研究包括两组；第1组，营养不良婴儿（n = 24），第2组；健康婴儿（n = 21）。采集参与者的外周血以研究微量营养素和LC-PUFA水平。通过使用安卡拉发育筛查量表测试来分析神经认知发育。对所有婴儿进行MRS检查。

结果

在重度营养不良的婴儿中，神经认知发育的所有参数以及血清钙（9.6±0.9mg/dL对10.4±0.3mg/dL，<0.05）和镁（2.02±0.27mg/dL对2.2±0.14mg/dL，<0.05）水平均较低。健康婴儿和营养不良婴儿的LC-PUFA水平没有差异。营养不良婴儿的丘脑胆碱/肌酸水平显著较高（1.33±0.22对1.18±0.22，<0.05）。婴儿的总体神经认知发育与血清钙水平呈正相关（<0.05；r=0.381）。