中轻度急性营养不良幼儿全血多不饱和脂肪酸的相关因素。
Correlates of whole-blood polyunsaturated fatty acids among young children with moderate acute malnutrition.
机构信息
Centre de Recherche en Sciences Biologiques, Alimentaires et Nutritionnelles, Université Ouaga I Prof Joseph KI-ZERBO, Ouagadougou, Burkina Faso.
Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg C, Denmark.
出版信息
Nutr J. 2017 Jul 13;16(1):44. doi: 10.1186/s12937-017-0264-3.
BACKGROUND
Severe acute malnutrition (SAM) has been associated with low polyunsaturated fatty acid (PUFA) status. However, investigations regarding PUFA status and correlates in children with moderate acute malnutrition (MAM) from low-income countries are scarce. The aim of this study was to describe whole-blood PUFA levels in children with moderate acute malnutrition (MAM) and to identify correlates of PUFAs.
METHODS
We conducted a cross-sectional study using baseline data from a prospective nutritional intervention trial among 1609 children with MAM aged 6-23 months in Burkina Faso,West Africa. Whole-blood PUFAs were measured by gas chromatography and expressed as percent of total whole-blood fatty acids (FA%). Potential correlates of PUFAs including infection, inflammation, hemoglobin, anthropometry (difference between children diagnosed as having MAM based on low mid-upper-arm-circumference (MUAC) only, low MUAC and weight-for-height z-score (WHZ), or low WHZ only) and diet were assessed by linear regression adjusted for age and sex.
RESULTS
Children with MAM had low concentrations of whole-blood PUFAs, particularly n-3 PUFAs. Moreover, children diagnosed with MAM based only on low MUAC had 0.32 (95% confidence interval (CI), 0.14; 0.50) and 0.40 (95% CI, 0.16; 0.63) FA% lower arachidonic acid (AA) than those recruited based on both low WHZ as well as low MUAC and those recruited with low WHZ only, respectively. Infection and inflammation were associated with low levels of all long-chain (LC)-PUFAs, while hemoglobin was positively associated with whole-blood LC-PUFAs.
CONCLUSION
While PUFA deficiency was not a general problem, overall whole-blood PUFA concentrations, especially of n-3 PUFAs, were low. Infection, inflammation, hemoglobin, anthropometry and diet were correlates of PUFAs concentrations in children with MAM.
TRIAL REGISTRATION
The trial is registered at http://www.isrctn.com ( ISRCTN42569496 ).
背景
严重急性营养不良（SAM）与多不饱和脂肪酸（PUFA）状态较低有关。然而，来自低收入国家的中度急性营养不良（MAM）儿童的 PUFA 状态及其相关性的研究很少。本研究的目的是描述中度急性营养不良（MAM）儿童的全血 PUFA 水平，并确定 PUFA 的相关因素。
方法
我们进行了一项横断面研究，使用来自布基纳法索 1609 名 6-23 个月大的 MAM 儿童的前瞻性营养干预试验的基线数据。通过气相色谱法测量全血 PUFAs，并表示为总全血脂肪酸（FA%）的百分比。通过线性回归评估感染、炎症、血红蛋白、人体测量学（仅根据低上臂中部周长（MUAC）、低 MUAC 和身高体重 Z 评分（WHZ）或仅低 WHZ 诊断为患有 MAM 的儿童之间的差异）和饮食与 PUFA 的相关性，调整年龄和性别。
结果
MAM 儿童的全血 PUFAs 浓度较低，特别是 n-3 PUFAs。此外，仅根据低 MUAC 诊断为 MAM 的儿童的花生四烯酸（AA）浓度比根据低 WHZ 以及低 MUAC 和低 WHZ 招募的儿童低 0.32（95%置信区间（CI），0.14；0.50）和 0.40（95%CI，0.16；0.63）FA%。感染和炎症与所有长链（LC）-PUFAs 水平较低有关，而血红蛋白与全血 LC-PUFA 呈正相关。
结论
虽然 PUFA 缺乏不是一个普遍问题，但全血 PUFA 浓度总体较低，尤其是 n-3 PUFAs。感染、炎症、血红蛋白、人体测量学和饮食是 MAM 儿童 PUFAs 浓度的相关因素。
试验注册
该试验在 http://www.isrctn.com 注册（ISRCTN42569496）。
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