Nishikiori T, Naganawa H, Muraoka Y, Aoyagi T, Umezawa H
J Antibiot (Tokyo). 1986 Jun;39(6):755-61. doi: 10.7164/antibiotics.39.755.
Plipastatins are new inhibitors of phospholipase A2 produced by Bacillus cereus BMG302-fF67. Structures of the plipastatins have been determined by UV, mass and NMR spectrometries and chemical degradation. The carboxyl group of the C-terminal L-isoleucine of plipastatinic acid has been shown to form a lactone linkage with the hydroxyl group of L-tyrosine. The total structure of plipastatins has thus been established.
