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Pain Pract. 2020 Feb;20(2):168-178. doi: 10.1111/papr.12841. Epub 2019 Oct 18.

本文引用的文献

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Sensitivities to Thermal and Mechanical Stimuli: Adults With Sickle Cell Disease Compared to Healthy, Pain-Free African American Controls.对热和机械刺激的敏感性：与健康、无痛的非裔美国对照相比，镰状细胞病患者。
J Pain. 2020 Sep-Oct;21(9-10):957-967. doi: 10.1016/j.jpain.2019.11.002. Epub 2019 Nov 13.
2
CaMKIIα underlies spontaneous and evoked pain behaviors in Berkeley sickle cell transgenic mice.钙调蛋白激酶IIα是伯克利镰状细胞转基因小鼠自发和诱发疼痛行为的基础。
Pain. 2016 Dec;157(12):2798-2806. doi: 10.1097/j.pain.0000000000000704.
3
Implementing the PAIN RelieveIt Randomized Controlled Trial in Hospice Care: Mechanisms for Success and Meeting PCORI Methodology Standards.在临终关怀中开展疼痛缓解随机对照试验：成功机制及符合PCORI方法标准
West J Nurs Res. 2017 Jul;39(7):924-941. doi: 10.1177/0193945916668328. Epub 2016 Sep 12.
4
A PROMIS Measure of Neuropathic Pain Quality.一种用于测量神经性疼痛性质的患者报告结果测量信息系统指标
Value Health. 2016 Jul-Aug;19(5):623-30. doi: 10.1016/j.jval.2016.02.009. Epub 2016 Apr 6.
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PKCδ-targeted intervention relieves chronic pain in a murine sickle cell disease model.蛋白激酶Cδ靶向干预可缓解小鼠镰状细胞病模型中的慢性疼痛。
J Clin Invest. 2016 Aug 1;126(8):3053-7. doi: 10.1172/JCI86165. Epub 2016 Jun 27.
6
Pain Intensity and Misconceptions Among Hospice Patients With Cancer and Their Caregivers: Status After 2 Decades.癌症临终关怀患者及其照顾者的疼痛强度与误解：二十年后的状况
Am J Hosp Palliat Care. 2017 May;34(4):318-324. doi: 10.1177/1049909116639612. Epub 2016 Mar 22.
7
Early insights into the neurobiology of pain in sickle cell disease: A systematic review of the literature.镰状细胞病疼痛神经生物学的早期见解：文献系统综述
Pediatr Blood Cancer. 2015 Sep;62(9):1501-11. doi: 10.1002/pbc.25574. Epub 2015 May 13.
8
Safety and Utility of Quantitative Sensory Testing among Adults with Sickle Cell Disease: Indicators of Neuropathic Pain?镰状细胞病成人患者定量感觉测试的安全性与实用性：神经性疼痛指标？
Pain Pract. 2016 Mar;16(3):282-93. doi: 10.1111/papr.12279. Epub 2015 Jan 12.
9
The role of screening tools in diagnosing neuropathic pain.筛查工具在诊断神经性疼痛中的作用。
Pain Manag. 2014 May;4(3):233-43. doi: 10.2217/pmt.14.8.
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Sickle cell mice exhibit mechanical allodynia and enhanced responsiveness in light touch cutaneous mechanoreceptors.镰状细胞小鼠表现出机械性触诱发痛和对轻触皮肤机械感受器的反应增强。
Mol Pain. 2012 Sep 10;8:62. doi: 10.1186/1744-8069-8-62.

神经病理性疼痛筛查：镰状细胞病患者的结构效度。

Neuropathic Pain Screening: Construct Validity in Patients With Sickle Cell Disease.

机构信息

University of Florida, Gainesville, FL, USA.

The University of Illinois at Chicago, IL, USA.

出版信息

West J Nurs Res. 2020 Feb;42(2):125-130. doi: 10.1177/0193945919836446. Epub 2019 Mar 22.

DOI:10.1177/0193945919836446
PMID:30900520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7716266/
Abstract

Individuals with pain from sickle cell disease (SCD) are often treated for nociceptive pain, but recent findings indicate they may also have neuropathic pain. PAINIt, a computerized version of the McGill Pain Questionnaire, provides a potential subscale that is the summed number of selected neuropathic pain quality words (PR-NNP), but it lacks construct validity. The study purpose was to ascertain PR-NNP construct validity in adults with SCD and chronic pain. In an outpatient setting, 186 participants completed the PAINIt, Neuropathic Pain Symptom Inventory (NPSI), and Leeds Assessment for Neuropathic Symptoms and Signs (S-LANSS). PR-NNP was moderately correlated with NPSI ( = .33, < .001) and S-LANSS ( = .40, < .001). Regression analysis indicated that PR-NNP and pain intensity, but not a nociceptive pain subscale, were significant predictors of NPSI and S-LANSS. Findings support construct validity of PR-NNP, which may be useful as a screening tool for neuropathic pain in patients with SCD.

摘要

患有镰状细胞病 (SCD) 的疼痛个体通常接受伤害感受性疼痛治疗，但最近的研究结果表明，他们也可能患有神经病理性疼痛。PAINIt 是麦吉尔疼痛问卷的计算机化版本，提供了一个潜在的分量表，即所选神经病理性疼痛质量词的总和（PR-NNP），但缺乏结构效度。该研究旨在确定 SCD 合并慢性疼痛患者的 PR-NNP 结构效度。在门诊环境中，186 名参与者完成了 PAINIt、神经病理性疼痛症状量表 (NPSI) 和 Leeds 评估神经病理性症状和体征 (S-LANSS)。PR-NNP 与 NPSI（r =.33，<.001）和 S-LANSS（r =.40，<.001）中度相关。回归分析表明，PR-NNP 和疼痛强度，但不是伤害感受性疼痛分量表，是 NPSI 和 S-LANSS 的显著预测因子。研究结果支持 PR-NNP 的结构效度，它可能是 SCD 患者神经病理性疼痛筛查工具的有用工具。