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1
Capacity of purified Lyt-2+ T cells to mount primary proliferative and cytotoxic responses to Ia- tumour cells.纯化的Lyt-2⁺ T细胞对Ia⁻肿瘤细胞产生初次增殖反应和细胞毒性反应的能力。
Nature. 1986;322(6079):541-4. doi: 10.1038/322541a0.
2
Properties of purified T cell subsets. I. In vitro responses to class I vs. class II H-2 alloantigens.纯化T细胞亚群的特性。I. 对I类与II类H-2同种异体抗原的体外反应。
J Exp Med. 1985 Dec 1;162(6):2068-88. doi: 10.1084/jem.162.6.2068.
3
Absence of the Lyt-2-,L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function.新生期用抗I-A处理的小鼠中Lyt-2-、L3T4+ T细胞系的缺失与胸腺内携带I-A的抗原呈递细胞功能的缺失相关。
J Exp Med. 1985 May 1;161(5):1029-47. doi: 10.1084/jem.161.5.1029.
4
The role of L3T4 in T cell activation: L3T4 may be both an Ia-binding protein and a receptor that transduces a negative signal.L3T4在T细胞激活中的作用：L3T4可能既是一种Ia结合蛋白，也是一种传递负信号的受体。
J Mol Cell Immunol. 1986;2(4):179-90.
5
Differential effects of antibodies to Lyt-2 and L3T4 on cytolysis by cloned, Ia-restricted T cells expressing both proteins.抗Lyt-2和L3T4抗体对表达这两种蛋白的克隆化、受Ia限制的T细胞介导的细胞溶解作用的差异效应。
J Immunol. 1987 Jul 15;139(2):380-4.
6
Relationship among function, phenotype, and specificity in primary allospecific T cell populations: identification of phenotypically identical but functionally distinct primary T cell subsets that differ in their recognition of MHC class I and class II allodeterminants.原发性同种特异性T细胞群体中功能、表型和特异性之间的关系：鉴定表型相同但功能不同的原发性T细胞亚群，这些亚群在对MHC I类和II类同种异体决定簇的识别上存在差异。
J Immunol. 1987 Jan 1;138(1):10-7.
7
Characterization of two distinct primary T cell populations that secrete interleukin 2 upon recognition of class I or class II major histocompatibility antigens.两种不同的初始T细胞群体的特征，这两种群体在识别I类或II类主要组织相容性抗原后会分泌白细胞介素2 。
J Exp Med. 1986 Mar 1;163(3):603-19. doi: 10.1084/jem.163.3.603.
8
Both L3T4+ and Lyt-2+ helper T cells initiate cytotoxic T lymphocyte responses against allogenic major histocompatibility antigens but not against trinitrophenyl-modified self.L3T4+辅助性T细胞和Lyt-2+辅助性T细胞均可启动针对同种异体主要组织相容性抗原的细胞毒性T淋巴细胞反应，但不针对三硝基苯修饰的自身抗原。
J Exp Med. 1985 Aug 1;162(2):427-43. doi: 10.1084/jem.162.2.427.
9
Involvement of Lyt-2 and L3T4 in activation of hapten-specific Lyt-2+ L3T4+ T-cell clones.Lyt-2和L3T4参与半抗原特异性Lyt-2⁺L3T4⁺T细胞克隆的激活。
Proc Natl Acad Sci U S A. 1986 Apr;83(8):2594-8. doi: 10.1073/pnas.83.8.2594.
10
Capacity of purified unprimed Lyt-2+ cells to reject Ia- H-2-different tumor cells in the Winn assay.
J Immunol. 1988 May 1;140(9):2899-902.

引用本文的文献

1
Requirements for bone marrow-derived antigen-presenting cells in priming cytotoxic T cell responses to intracellular pathogens.启动细胞毒性T细胞对细胞内病原体反应时骨髓来源的抗原呈递细胞的要求。
J Exp Med. 2000 Oct 16;192(8):1135-42. doi: 10.1084/jem.192.8.1135.
2
HL-60 myeloid leukaemia cells acquire immunostimulatory capability upon treatment with retinoic acid: analysis of the responding population and mechanism of cytotoxic lymphocyte activation.HL-60髓系白血病细胞经视黄酸处理后获得免疫刺激能力：对反应群体及细胞毒性淋巴细胞激活机制的分析
Immunology. 1996 Jul;88(3):428-40. doi: 10.1046/j.1365-2567.1996.d01-668.x.
3
Resting and activated T cells display different requirements for CD8 molecules.静息和活化的T细胞对CD8分子表现出不同的需求。
J Exp Med. 1994 Jun 1;179(6):2005-15. doi: 10.1084/jem.179.6.2005.
4
Cellular immune responses induced by in vivo priming with a lipid-conjugated multimeric antigen peptide.通过用脂质偶联的多聚体抗原肽进行体内致敏诱导的细胞免疫反应。
Immunology. 1993 Jul;79(3):355-61.
5
B-cell-stimulatory factor 2 (beta 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells.B细胞刺激因子2（β2干扰素）作为成熟小鼠T细胞产生白细胞介素2的第二信号发挥作用。
Proc Natl Acad Sci U S A. 1987 Nov;84(21):7629-33. doi: 10.1073/pnas.84.21.7629.
6
The autonomy of CD8+ T cells in vitro and in vivo.CD8 + T细胞在体外和体内的自主性。
Immunology. 1988 Oct;65(2):249-57.
7
T4+ T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody responses.体内T4 +辅助性T细胞功能：诱导抗病毒细胞毒性T细胞和抗体反应的不同需求。
J Virol. 1988 Jun;62(6):2102-6. doi: 10.1128/JVI.62.6.2102-2106.1988.
8
L3T4 and Lyt-2 T cells are both involved in the generation of low-dose streptozotocin-induced diabetes in mice.L3T4和Lyt-2 T细胞都参与了低剂量链脲佐菌素诱导的小鼠糖尿病的发生。
Clin Exp Immunol. 1987 Dec;70(3):585-92.
9
Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells.树突状细胞对CD8 + 细胞毒性T淋巴细胞的直接激活。
J Exp Med. 1987 Jul 1;166(1):182-94. doi: 10.1084/jem.166.1.182.
10
Anti-L3T4 antibody inhibits the lysis of H-2 class II antigen-negative target cells by L3T4+ cytotoxic T lymphocytes.抗L3T4抗体可抑制L3T4 + 细胞毒性T淋巴细胞对H-2 II类抗原阴性靶细胞的裂解作用。
Proc Natl Acad Sci U S A. 1988 Jul;85(14):5205-9. doi: 10.1073/pnas.85.14.5205.

本文引用的文献

1
Role of lymphokine and antigen in the control of specific T cell responses.淋巴因子和抗原在特异性T细胞反应控制中的作用。
Immunol Rev. 1980;51:279-314. doi: 10.1111/j.1600-065x.1980.tb00325.x.
2
The role of Ia molecules in the activation of T lymphocytes. II. Ia-restricted recognition of allo K/D antigens is required for class I MHC-stimulated mixed lymphocyte responses.Ia分子在T淋巴细胞激活中的作用。II. I类主要组织相容性复合体刺激的混合淋巴细胞反应需要Ia限制的同种异体K/D抗原识别。
J Immunol. 1983 Jan;130(1):457-62.
3
T cell subsets and the recognition of MHC class.T细胞亚群与主要组织相容性复合体（MHC）类分子的识别
Immunol Rev. 1983;74:129-42. doi: 10.1111/j.1600-065x.1983.tb01087.x.
4
Responses to the H-2Kba mutant involve recognition of syngeneic Ia molecules.对H-2Kba突变体的反应涉及对同基因Ia分子的识别。
Nature. 1983;302(5907):429-31. doi: 10.1038/302429a0.
5
Functional clonal deletion of class I-specific cytotoxic T lymphocytes by veto cells that express antigen.通过表达抗原的否决细胞对I类特异性细胞毒性T淋巴细胞进行功能性克隆清除。
J Immunol. 1984 Nov;133(5):2390-6.
6
Lyt-2- T cell-independent functions of Lyt-2+ cells stimulated with antigen or concanavalin A.用抗原或刀豆球蛋白A刺激的Lyt-2⁺细胞的Lyt-2⁻非T细胞依赖性功能。
J Immunol. 1984 Jul;133(1):59-64.
7
T cell-accessory cell interactions that initiate allospecific cytotoxic T lymphocyte responses: existence of both Ia-restricted and Ia-unrestricted cellular interaction pathways.引发同种特异性细胞毒性T淋巴细胞反应的T细胞-辅助细胞相互作用：Ia限制型和Ia非限制型细胞相互作用途径的存在。
J Immunol. 1984 May;132(5):2199-209.
8
Expression of both I-A and I-E/C subregion antigens on accessory cells required for in vitro generation of cytotoxic T lymphocytes against alloantigens or TNBS-modified syngeneic cells.在体外产生针对同种异体抗原或经三硝基苯磺酸修饰的同基因细胞的细胞毒性T淋巴细胞所需的辅助细胞上，I-A和I-E/C亚区抗原均有表达。
J Immunol. 1980 Apr;124(4):1911-6.
9
Properties of purified T cell subsets. I. In vitro responses to class I vs. class II H-2 alloantigens.纯化T细胞亚群的特性。I. 对I类与II类H-2同种异体抗原的体外反应。
J Exp Med. 1985 Dec 1;162(6):2068-88. doi: 10.1084/jem.162.6.2068.
10
Search for class II major histocompatibility complex molecular involvement in the response of Lyt-2+ cytotoxic T lymphocyte precursors to alloantigen.寻找II类主要组织相容性复合体分子在Lyt-2+细胞毒性T淋巴细胞前体对同种异体抗原反应中的作用。
Eur J Immunol. 1985 Nov;15(11):1125-30. doi: 10.1002/eji.1830151111.

纯化的Lyt-2⁺ T细胞对Ia⁻肿瘤细胞产生初次增殖反应和细胞毒性反应的能力。

Capacity of purified Lyt-2+ T cells to mount primary proliferative and cytotoxic responses to Ia- tumour cells.

作者信息

Sprent J, Schaefer M

出版信息

Nature. 1986;322(6079):541-4. doi: 10.1038/322541a0.

DOI:10.1038/322541a0
PMID:3090451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7095433/
Abstract

Allogeneic gene products of the major histocompatibility complex, the HLA complex in man and the H-2 complex in mice, induce T lymphocytes to exert powerful mixed lymphocyte reactions (MLR) and cell-mediated lympholysis (CML). In mice, the subset of T cells carrying the L3T4 surface antigen but lacking the Lyt-2 antigen responds predominantly to H-2 class II (Ia) differences whereas the L3T4- Lyt-2+ subset reacts to class I (K/D) differences. For primary responses the stimulus for MLR and CML appears to be controlled by Ia+ cells of the macrophage/dendritic cell lineages, for both L3T4+ and Lyt-2+ cells. The finding that Ia+ cells are required for responses involving Lyt-2+ cells has been taken to imply that triggering of these cells is controlled by Ia-restricted L3T4+ cells. Lyt-2+ cells have thus come to be regarded as crippled cells which are heavily dependent on 'help' from other T cells. This well-entrenched view is challenged by evidence presented here that purified Lyt-2+ cells can give high primary responses to certain Ia- tumour cells in vitro.

摘要

主要组织相容性复合体的同种异体基因产物，即人类的HLA复合体和小鼠的H-2复合体，可诱导T淋巴细胞产生强烈的混合淋巴细胞反应（MLR）和细胞介导的淋巴细胞溶解（CML）。在小鼠中，携带L3T4表面抗原但缺乏Lyt-2抗原的T细胞亚群主要对H-2Ⅱ类（Ia）差异作出反应，而L3T4-Lyt-2+亚群则对Ⅰ类（K/D）差异作出反应。对于初次反应，MLR和CML的刺激似乎由巨噬细胞/树突状细胞谱系的Ia+细胞控制，对于L3T4+和Lyt-2+细胞均如此。Ia+细胞参与涉及Lyt-2+细胞的反应这一发现被认为意味着这些细胞的触发由Ia限制的L3T4+细胞控制。因此，Lyt-2+细胞被视为严重依赖其他T细胞“帮助”的残废细胞。本文提供的证据对这一根深蒂固的观点提出了挑战，即纯化的Lyt-2+细胞在体外可对某些Ia-肿瘤细胞产生高效的初次反应。