Rammensee H G, Fink P J, Bevan M J
J Immunol. 1984 Nov;133(5):2390-6.
Intravenous injection of class I incompatible spleen cells into mice results in a drastic reduction of the recipient's cytotoxic T lymphocyte (CTL) response against the injected, but not against third party, class I antigens when measured in bulk cultures initiated 5 to 6 days after the injection. This specific suppressive effect is partly due to T cells but can also be seen when high numbers of anti-Thy-1 and complement-treated spleen cells of nude mice are injected. Such cells suppressing CTL responses against self histocompatibility antigens are called "veto cells." The precursor frequency of CTL specific for the injected class I antigen is found to be reduced greater than 200-fold at days 5 to 6 after the injection, whereas the frequencies of CTL specific for third party class I antigens are not significantly changed. These results indicate that there is a functional clonal deletion of the CTL recognizing class I incompatible veto cells in vivo. The role of such a veto phenomenon in the induction and maintenance of self tolerance and allograft tolerance is discussed.
给小鼠静脉注射I类不相容的脾细胞后，在注射后5至6天启动的大量培养物中检测时，受体针对注射的I类抗原而非第三方I类抗原的细胞毒性T淋巴细胞（CTL）反应会急剧降低。这种特异性抑制作用部分归因于T细胞，但当注射大量经抗Thy-1和补体处理的裸鼠脾细胞时也能观察到。这种抑制针对自身组织相容性抗原的CTL反应的细胞被称为“否决细胞”。发现在注射后第5至6天，针对注射的I类抗原的CTL前体频率降低超过200倍，而针对第三方I类抗原的CTL频率没有显著变化。这些结果表明，在体内存在识别I类不相容否决细胞的CTL功能性克隆缺失。本文讨论了这种否决现象在自身耐受和同种异体移植耐受的诱导和维持中的作用。
