T细胞系和肥大细胞系对B细胞刺激因子1产生反应。
T-cell and mast cell lines respond to B-cell stimulatory factor 1.
作者信息
Mosmann T R, Bond M W, Coffman R L, Ohara J, Paul W E
出版信息
Proc Natl Acad Sci U S A. 1986 Aug;83(15):5654-8. doi: 10.1073/pnas.83.15.5654.
Abstract
The murine lymphokine B-cell stimulatory factor 1 (BSF-1) has been described previously in terms of its action on B lymphocytes. We now provide evidence that BSF-1 is also responsible for two additional biological activities. The first of these is the stimulation or maintenance of a state of activation in mouse T-cell lines. The second activity is the increase in the proliferative rate of certain mast cell lines costimulated with interleukin 3. The T-cell and mast cell activities are mediated by purified BSF-1 and copurify with BSF-1 from supernatants of certain T-cell lines. Each of these activities is inhibited by monoclonal anti-BSF-1 but not by monoclonal anti-interleukin 2 antibody. The antibody inhibition results also indicate that BSF-1 is the major or only source of these two activities in the activated T-cell supernatants that we have tested.
摘要
鼠淋巴细胞刺激因子1（BSF-1）先前已根据其对B淋巴细胞的作用进行过描述。我们现在提供证据表明，BSF-1还具有另外两种生物学活性。其中第一种是刺激或维持小鼠T细胞系的激活状态。第二种活性是在与白细胞介素3共同刺激时某些肥大细胞系增殖速率的增加。T细胞和肥大细胞活性由纯化的BSF-1介导，并与来自某些T细胞系上清液的BSF-1共纯化。这些活性中的每一种都被抗BSF-1单克隆抗体抑制，但不被抗白细胞介素2单克隆抗体抑制。抗体抑制结果还表明，在我们测试的活化T细胞上清液中，BSF-1是这两种活性的主要或唯一来源。
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