B细胞刺激因子的纯化至均一性。一种刺激多种淋巴因子依赖细胞系增殖的分子。
Purification to homogeneity of B cell stimulating factor. A molecule that stimulates proliferation of multiple lymphokine-dependent cell lines.
作者信息
Grabstein K, Eisenman J, Mochizuki D, Shanebeck K, Conlon P, Hopp T, March C, Gillis S
出版信息
J Exp Med. 1986 Jun 1;163(6):1405-14. doi: 10.1084/jem.163.6.1405.
Abstract
Murine B cell stimulating factor 1 (BSF-1) was purified to homogeneity from supernatants of a stimulated thymoma cell line. A protein of 18.4 kD with a unique N-terminal amino acid sequence was identified. BSF-1 had a sp act of at least 3.28 X 10(8) U/mg. In addition to its B cell-stimulatory activity, BSF-1 also stimulated the proliferation of several IL-2- and IL-3-dependent cell lines. We conclude that BSF-1 is both a growth factor and a differentiation factor. Finally, these results also suggest additional biologic properties of BSF-1 on lineages besides B lymphocytes.
摘要
从小鼠胸腺瘤细胞系的培养上清液中纯化出了具有同质性的小鼠B细胞刺激因子1（BSF-1）。鉴定出一种分子量为18.4 kD、具有独特N端氨基酸序列的蛋白质。BSF-1的比活性至少为3.28×10⁸ U/mg。除了其B细胞刺激活性外，BSF-1还能刺激几种依赖白细胞介素-2和白细胞介素-3的细胞系的增殖。我们得出结论，BSF-1既是一种生长因子也是一种分化因子。最后，这些结果还表明BSF-1除了对B淋巴细胞系外，对其他细胞系也具有额外的生物学特性。
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本文引用的文献
1
Identification of a T cell-derived b cell growth factor distinct from interleukin 2.一种不同于白细胞介素2的T细胞源性B细胞生长因子的鉴定。
J Exp Med. 1982 Mar 1;155(3):914-23. doi: 10.1084/jem.155.3.914.
2
Growth of factor-dependent hemopoietic precursor cell lines.因子依赖性造血前体细胞系的生长
J Exp Med. 1980 Oct 1;152(4):1036-47. doi: 10.1084/jem.152.4.1036.
3
Establishing homologies in protein sequences.确定蛋白质序列中的同源性。
Methods Enzymol. 1983;91:524-45. doi: 10.1016/s0076-6879(83)91049-2.
4
Partial purification and characterization of a BCGFII from EL4 culture supernatants.从EL4培养上清液中对一种白细胞介素-2的B细胞生长因子（BCGFII）进行部分纯化及特性鉴定。
J Immunol. 1984 May;132(5):2451-6.
5
Purification to homogeneity and partial characterization of interleukin 2 from a human T-cell leukemia.从人T细胞白血病中纯化白细胞介素2至均一性并进行部分特性鉴定。
Proc Natl Acad Sci U S A. 1984 Feb;81(3):871-5. doi: 10.1073/pnas.81.3.871.
6
7
Activation of granulocyte cytotoxic function by purified mouse colony-stimulating factors.纯化的小鼠集落刺激因子对粒细胞细胞毒性功能的激活作用。
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8
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Proc Natl Acad Sci U S A. 1984 Oct;81(19):6149-53. doi: 10.1073/pnas.81.19.6149.
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Interleukin-induced increase in Ia expression by normal mouse B cells.白细胞介素诱导正常小鼠B细胞Ia表达增加。
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