Mosmann T R, Yokota T, Kastelein R, Zurawski S M, Arai N, Takebe Y
J Immunol. 1987 Mar 15;138(6):1813-6.
Mouse and human interleukin 2 (IL 2) both cause proliferation of T cells of the homologous species at high efficiency. Human IL 2 also stimulates proliferation of mouse T cells at similar concentrations, whereas mouse IL 2 stimulates human T cells at a lower (sixfold to 170-fold) efficiency. In contrast, the T cell stimulating activities of mouse and human B cell stimulatory factor 1 (interleukin 4; IL 4) appear to be species specific over the range of concentrations tested; we detected no activity of mouse IL 4 on human T cells, or human IL 4 on mouse T cells.
小鼠和人白细胞介素2（IL-2）均能高效地引起同源物种T细胞的增殖。人IL-2在相似浓度下也能刺激小鼠T细胞的增殖，而小鼠IL-2刺激人T细胞的效率较低（6倍至170倍）。相比之下，在测试的浓度范围内，小鼠和人B细胞刺激因子1（白细胞介素4；IL-4）的T细胞刺激活性似乎具有物种特异性；我们未检测到小鼠IL-4对人T细胞的活性，或人IL-4对小鼠T细胞的活性。
