Schaadt M, Diehl V, Kalden J R, Schmidt N, Laskewitz E
Med Klin. 1978 Oct 6;73(40):1381-8.
In a total group of 103 Hodgkin's disease patients the immune-status of splenectomized and non-splenectomized individuals is compared in subgroups characterized by the modality of treatment (RT, CT, RCT). The mitogenic stimulation of peripheral lymphocytes showed a decreased response of splenectomized patients in each therapy group. The percentage, but not the absolute number/mm3, of peripheral T-cells was reduced after splenectomy. Splenectomized patients, who received combined radiation and chemotherapy showed significantly lower IgM-levels than non-splenectomized patients after the same treatment. EBV-VCA-titers and skin-test-reactivity were not influenced by splenectomy.
在总共103例霍奇金病患者中，根据治疗方式（放疗、化疗、放化疗联合）分为亚组，比较了脾切除患者和未脾切除患者的免疫状态。外周淋巴细胞的丝裂原刺激显示，各治疗组中脾切除患者的反应均降低。脾切除后外周T细胞的百分比降低，但每立方毫米的绝对数量未降低。接受放疗和化疗联合治疗的脾切除患者，在相同治疗后，其IgM水平显著低于未脾切除患者。脾切除对外周血EB病毒壳抗原滴度和皮肤试验反应性没有影响。
