Department of Oral Pathology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, 2 Eftimie Murgu Sq., 300041, Romania.
Department of Anaesthesiology and Oral Surgery, "Victor Babeș" University of Medicine and Pharmacy, Timisoara, 2 Eftimie Murgu Sq., 300041, Romania.
Dis Markers. 2019 Feb 17;2019:8761860. doi: 10.1155/2019/8761860. eCollection 2019.
Early diagnosis represents the target of contemporary medicine and has an important role in the prognosis and further treatment. Saliva is a biofluid that generated a high interest among researchers due to its multiple advantages over other body fluids. The multitude of components that can act as biomarkers influenced the existing technologies to develop protocols that could allow saliva to become the new noninvasive diagnostic method. Saliva as a diagnostic tool can bring substantial addition to the diagnostic armamentarium, providing important information about oral and general health. The diagnostic applications of saliva extended and had a rapid evolution due to the advancement in salivaomics. The present review summarizes the latest researches in saliva-related studies and explores the information and correlations that saliva can offer regarding the systemic and oral diseases, highlighting its great potential of diagnosis. It is expected that in the future specific guidelines and results regarding the salivary diagnostics are to be available, together with high-sensitivity and specificity tests for multiple systemic and oral diseases.
早期诊断是当代医学的目标，对预后和进一步治疗具有重要作用。唾液是一种生物流体，由于其相对于其他体液的多种优势，引起了研究人员的极大兴趣。作为生物标志物的多种成分影响了现有技术的发展，以开发能够使唾液成为新的非侵入性诊断方法的方案。唾液作为一种诊断工具可以为诊断工具带来实质性的补充，提供有关口腔和整体健康的重要信息。由于唾液组学的进步，唾液的诊断应用得到了扩展和快速发展。本文综述了唾液相关研究的最新进展，探讨了唾液在系统性和口腔疾病方面提供的信息和相关性，突出了其在诊断方面的巨大潜力。预计未来将有关于唾液诊断的具体指南和结果，并针对多种系统性和口腔疾病开发具有高灵敏度和特异性的检测方法。
