Wang Chonghe, Li Xiaoshi, Hu Hongjie, Zhang Lin, Huang Zhenlong, Lin Muyang, Zhang Zhuorui, Yin Zhenan, Huang Brady, Gong Hua, Bhaskaran Shubha, Gu Yue, Makihata Mitsutoshi, Guo Yuxuan, Lei Yusheng, Chen Yimu, Wang Chunfeng, Li Yang, Zhang Tianjiao, Chen Zeyu, Pisano Albert P, Zhang Liangfang, Zhou Qifa, Xu Sheng
Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
Materials Science and Engineering Program, University of California San Diego, La Jolla, CA, USA.
Nat Biomed Eng. 2018 Sep;2(9):687-695. doi: 10.1038/s41551-018-0287-x. Epub 2018 Sep 11.
Continuous monitoring of the central-blood-pressure waveform from deeply embedded vessels, such as the carotid artery and jugular vein, has clinical value for the prediction of all-cause cardiovascular mortality. However, existing non-invasive approaches, including photoplethysmography and tonometry, only enable access to the superficial peripheral vasculature. Although current ultrasonic technologies allow non-invasive deep-tissue observation, unstable coupling with the tissue surface resulting from the bulkiness and rigidity of conventional ultrasound probes introduces usability constraints. Here, we describe the design and operation of an ultrasonic device that is conformal to the skin and capable of capturing blood-pressure waveforms at deeply embedded arterial and venous sites. The wearable device is ultrathin (240 μm) and stretchable (with strains up to 60%), and enables the non-invasive, continuous and accurate monitoring of cardiovascular events from multiple body locations, which should facilitate its use in a variety of clinical environments.
持续监测来自如颈动脉和颈静脉等深埋血管的中心血压波形，对于预测全因心血管死亡率具有临床价值。然而，现有的非侵入性方法，包括光电容积脉搏波描记法和眼压测量法，仅能获取浅表外周血管系统的信息。尽管当前的超声技术允许进行非侵入性的深部组织观察，但传统超声探头的体积和刚性导致其与组织表面的耦合不稳定，从而带来了使用限制。在此，我们描述了一种与皮肤贴合、能够在深埋的动脉和静脉部位捕获血压波形的超声设备的设计与操作。该可穿戴设备超薄（240微米）且可拉伸（应变高达60%），能够从多个身体部位对心血管事件进行非侵入性、连续且准确的监测，这将有助于其在各种临床环境中的应用。
