Yuan Jiawei, Li Zhikang, Zhao Yihe, Luo Ruiyan, Qin Shaohui, Li Jie, Li Min, Han Gengyu, Li Zixuan, Zhao Zilong, Li Jiazhu, Zhang Shiwang, Yuan Zheng, Han Xiangguang, Fan Lihong, Wang Xiaozhang, Wang Tong, Yang Ping, Zhao Libo, Yuan Lirong, Lv Yi, Wu Rongqian, Hsiai Tzung K, Jiang Zhuangde
State Key Laboratory for Manufacturing System Engineering, State Industry-Education Integration Center for Medical Innovations, International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies, Shaanxi Innovation Center for Special Sensing and Testing Technology in Extreme Environments, Shaanxi Provincial University Engineering Research Center for Micro/Nano Acoustic Devices and Intelligent Systems, Xi'an Jiaotong University, Xi'an 710049, China.
School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an 710049, China.
Sci Adv. 2025 Sep 12;11(37):eadw7632. doi: 10.1126/sciadv.adw7632. Epub 2025 Sep 10.
Continuous monitoring of cardiovascular vital signs can reduce the incidence and mortality of cardiovascular diseases, yet cannot be implemented by current technologies because of device bulkiness and rigidity. Here, we report self-adhesive and skin-conformal ultrasonic transducer arrays that enable wearable monitoring of multiple hemodynamic parameters without interfering with daily activities. A skin-adaptive focused ultrasound method with rational array design is proposed to implement measurement under wide ranges of skin curvatures and depths with improved sensing performances. We introduce a self-adhesive hydrogel layer to enhance the acoustic impedance matching, biocompatibility and contact reliability at device-skin interfaces, and a microelectromechanical systems-compatible process for batch-to-batch and high-consistency manufacturing. The resultant transducer array, with a frequency of 2.4 megacycles per second and a -6 dB bandwidth of 47%, implements accurate and continuous detection of cardiovascular signs, including blood pressure (BP) waveforms of various arteries, heart rate and BP during exercises, and arterial stiffness, validated clinically.
持续监测心血管生命体征可降低心血管疾病的发病率和死亡率，但由于设备笨重且僵硬，目前的技术无法实现这一点。在此，我们报告了一种自粘性且贴合皮肤的超声换能器阵列，它能够在不干扰日常活动的情况下对多种血流动力学参数进行可穿戴监测。我们提出了一种具有合理阵列设计的皮肤自适应聚焦超声方法，以在广泛的皮肤曲率和深度范围内实现测量，并提高传感性能。我们引入了一种自粘性水凝胶层，以增强设备与皮肤界面处的声阻抗匹配、生物相容性和接触可靠性，以及一种与微机电系统兼容的工艺，用于批次间和高一致性制造。所得的换能器阵列，频率为每秒2.4兆周，-6分贝带宽为47%，实现了对心血管体征的准确连续检测，包括各种动脉的血压（BP）波形、运动期间的心率和血压，以及动脉僵硬度，并经过了临床验证。
