McMurray Justin P, DeVries Aubrey, Frazee Kendall, Sizemore Bailey, Branan Kimberly L, Jennings Richard, Coté Gerard L
Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA.
Texas A&M Engineering Experiment Station, Center for Remote Health Technologies and Systems, College Station, TX 77843, USA.
Biosensors (Basel). 2025 Jun 27;15(7):413. doi: 10.3390/bios15070413.
Cardiovascular disease (CVD) is the leading cause of global mortality, with hypertension affecting over one billion people. Current noninvasive blood pressure (BP) systems, like cuffs, suffer from discomfort and placement errors and lack continuous monitoring. Wearable solutions promise improvements, but technologies like photoplethysmography (PPG) and bioimpedance (BIOZ) face usability and clinical accuracy limitations. PPG is sensitive to skin tone and body mass index (BMI) variability, while BIOZ struggles with electrode contact and reusability. We present a novel, strain gauge-based wearable BP device that directly quantifies pressure via a dual transducer system, compensating for tissue deformation and external forces to enable continuous, accurate BP measurement. The reusable, energy-efficient, and compact design suits long-term daily use. A novel leg press protocol across 10 subjects (systolic: 71.04-241.42 mmHg, diastolic: 53.46-123.84 mmHg) validated its performance under dynamic conditions, achieving mean absolute errors of 2.45 ± 3.99 mmHg (systolic) and 1.59 ± 2.08 mmHg (diastolic). The device showed enhanced robustness compared to the Finapres, with less motion-induced noise. This technology significantly advances current methods by delivering continuous, real-time BP monitoring without reliance on electrodes, independent of skin tone, while maintaining a high accuracy and user comfort.
心血管疾病（CVD）是全球死亡的主要原因，高血压影响着超过10亿人。目前的无创血压（BP）系统，如袖带，存在不适感和放置错误的问题，且缺乏连续监测。可穿戴解决方案有望带来改进，但诸如光电容积脉搏波描记法（PPG）和生物阻抗（BIOZ）等技术面临可用性和临床准确性的限制。PPG对肤色和体重指数（BMI）变化敏感，而BIOZ在电极接触和可重复使用性方面存在困难。我们提出了一种基于应变计的新型可穿戴血压设备，该设备通过双传感器系统直接量化压力，补偿组织变形和外力，以实现连续、准确的血压测量。这种可重复使用、节能且紧凑的设计适合长期日常使用。一项针对10名受试者（收缩压：71.04 - 241.42 mmHg，舒张压：53.46 - 123.84 mmHg）的新型腿部按压方案验证了其在动态条件下的性能，收缩压平均绝对误差为2.45 ± 3.99 mmHg，舒张压平均绝对误差为1.59 ± 2.08 mmHg。与Finapres相比，该设备显示出更强的鲁棒性，运动引起的噪声更小。这项技术通过提供连续、实时的血压监测，无需依赖电极，不受肤色影响，同时保持高精度和用户舒适度，显著推进了现有方法。
