He Rong-Zhang, Luo Di-Xian, Mo Yin-Yuan
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410078 Hunan, China.
Translational Medicine Institute, National & Local Joint Engineering Laboratory for High-through Molecular Diagnosis Technology, Collaborative Research Center for Post-doctoral Mobile Stations of Central South University, Affiliated the First People's Hospital of Chenzhou of University of South China, Chenzhou, 432000, China.
Genes Dis. 2019 Feb 11;6(1):6-15. doi: 10.1016/j.gendis.2019.01.003. eCollection 2019 Mar.
Accumulating evidence indicates that long non-coding RNAs (lncRNAs) can play a pivotal role in regulation of diverse cellular processes. In particular, lncRNAs can serve as master gene regulators at transcriptional and posttranscriptional levels, leading to tumorigenesis. In this review, we discuss latest developments in lncRNA-meditated gene expression at the post-transcriptional level, including gene splicing, mRNA stability, protein stability and nuclear trafficking.
越来越多的证据表明，长链非编码RNA（lncRNA）在多种细胞过程的调控中发挥着关键作用。特别是，lncRNA可在转录和转录后水平作为主要基因调节因子，导致肿瘤发生。在本综述中，我们讨论了lncRNA介导的转录后水平基因表达的最新进展，包括基因剪接、mRNA稳定性、蛋白质稳定性和核运输。
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