Babiker M A
Trop Geogr Med. 1986 Jun;38(2):119-22.
42 children with impaired splenic function were followed-up for 8 months for compliance with penicillin prophylaxis. Parents of 24 children (group A) chose a twice daily oral while parents of 18 children (group B) chose a 3-weekly injection regimen. The penicillin intake was checked by the presence of antibacterial activity in urine obtained at clinic visits. The clinics attendance rate for both groups was 92.7% and 94.9% respectively. For group A 44% of urines tested were positive indicating poor compliance with oral medication over the previous 5 to 16 hours. The educational level of parents and age and sex of children did not influence compliance. It seems safer, therefore, to use an intramuscular regimen rather than rely on oral prophylaxis in children with impaired splenic function.
对42名脾功能受损儿童进行了为期8个月的青霉素预防依从性随访。24名儿童（A组）的家长选择每日口服两次，而18名儿童（B组）的家长选择每3周注射一次的方案。通过门诊就诊时采集尿液中的抗菌活性来检查青霉素摄入情况。两组的门诊就诊率分别为92.7%和94.9%。对于A组，44%的检测尿液呈阳性，表明在前5至16小时内口服药物的依从性较差。家长的教育水平以及儿童的年龄和性别均未影响依从性。因此，对于脾功能受损的儿童，采用肌肉注射方案似乎比依靠口服预防更安全。
