Abitbol M M, Monheit A G, Stone M L
Am J Obstet Gynecol. 1986 Aug;155(2):437-43. doi: 10.1016/0002-9378(86)90848-3.
In the fetal dog, simultaneous recording by transcutaneous PO2 and PCO2 and tissue pH electrodes were compared to corresponding arterial values during hypoxic episodes produced by occlusion of the maternal abdominal aorta. Before occlusion, the differences between the paired values were minimal. Under anoxic conditions, expected changes in the peripheral circulation were observed. However, the transcutaneous PO2 was lower, the transcutaneous PCO2 much higher, and the tissue pH much lower than in blood. Continuous electrodes demonstrate changes resulting from gas and hydrogen ion coming from cells more readily than blood because they are closer to the former. Additionally, carbon dioxide and hydrogen ion are buffered to a greater degree in blood than in cells. Consequently, under conditions of stress and active metabolism, PCO2 is higher while PO2 and pH are lower in cells than in blood. When compared with monitoring of gases and acid-base balance through blood sampling, continuous transcutaneous and intracutaneous monitoring would seem to be more representative of the environment at the cellular level.
在胎犬中，通过经皮氧分压（PO2）、二氧化碳分压（PCO2）和组织pH电极进行同步记录，并与母体腹主动脉闭塞导致缺氧发作期间相应的动脉值进行比较。在闭塞前，配对值之间的差异很小。在缺氧条件下，观察到外周循环的预期变化。然而，经皮PO2较低，经皮PCO2高得多，组织pH比血液中的低得多。连续电极比血液更容易显示来自细胞的气体和氢离子引起的变化，因为它们离细胞更近。此外，二氧化碳和氢离子在血液中的缓冲程度比在细胞中更大。因此，在应激和活跃代谢的情况下，细胞内的PCO2较高，而PO2和pH比血液中的低。与通过采血监测气体和酸碱平衡相比，连续经皮和皮内监测似乎更能代表细胞水平的环境。
