School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Basic Medical College, Jilin University, Changchun 130021, China.
Molecules. 2019 Mar 23;24(6):1159. doi: 10.3390/molecules24061159.
Meyer cv. Silvatica (PGS), which is also known as "Lin-Xia-Shan-Shen" or "Zi-Hai" in China, is grown in forests and mountains by broadcasting the seeds of ginseng and is harvested at the cultivation age of 15⁻20 years. In this study, four new dammarane-type triterpenoids, ginsengenin-S1 (), ginsengenin-S2 (), ginsenoside-S3 (), ginsenoside-S4 (), along with one known compound were isolated from pearl knots of PGS. Ginsengenin-S2 significantly alleviated oxidative damage when A549 cells were exposed to cigarette smoke (CS) extract. In addition, ginsengenin-S2 could inhibit the CS-induced inflammatory reaction in A549 cells. Protective effects of ginsengenin-S2 against CS-mediated oxidative stress and the inflammatory response in A549 cells may involve the Nrf2 and HDAC2 pathways.
美叶凤尾蕉（PGS），在中国也被称为“林下参”或“子海”，是通过广播人参种子在森林和山区种植的，收获期为 15⁻20 年。在这项研究中，从 PGS 的珍珠结中分离出四种新的达玛烷型三萜皂苷，人参皂苷 S1()、人参皂苷 S2()、人参皂苷 S3()和人参皂苷 S4()，以及一种已知化合物。当 A549 细胞暴露于香烟烟雾（CS）提取物时，人参皂苷 S2 显著减轻了氧化损伤。此外，人参皂苷 S2 可以抑制 CS 诱导的 A549 细胞炎症反应。人参皂苷 S2 对 CS 介导的 A549 细胞氧化应激和炎症反应的保护作用可能涉及 Nrf2 和 HDAC2 通路。
