四种新型达玛烷型三萜类化合物来自 Meyer cv. Silvatica 的珍珠结。
Four Novel Dammarane-Type Triterpenoids from Pearl Knots of Meyer cv. Silvatica.
机构信息
School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Basic Medical College, Jilin University, Changchun 130021, China.
出版信息
Molecules. 2019 Mar 23;24(6):1159. doi: 10.3390/molecules24061159.
Meyer cv. Silvatica (PGS), which is also known as "Lin-Xia-Shan-Shen" or "Zi-Hai" in China, is grown in forests and mountains by broadcasting the seeds of ginseng and is harvested at the cultivation age of 15⁻20 years. In this study, four new dammarane-type triterpenoids, ginsengenin-S1 (), ginsengenin-S2 (), ginsenoside-S3 (), ginsenoside-S4 (), along with one known compound were isolated from pearl knots of PGS. Ginsengenin-S2 significantly alleviated oxidative damage when A549 cells were exposed to cigarette smoke (CS) extract. In addition, ginsengenin-S2 could inhibit the CS-induced inflammatory reaction in A549 cells. Protective effects of ginsengenin-S2 against CS-mediated oxidative stress and the inflammatory response in A549 cells may involve the Nrf2 and HDAC2 pathways.
美叶凤尾蕉（PGS），在中国也被称为“林下参”或“子海”，是通过广播人参种子在森林和山区种植的，收获期为 15⁻20 年。在这项研究中，从 PGS 的珍珠结中分离出四种新的达玛烷型三萜皂苷，人参皂苷 S1()、人参皂苷 S2()、人参皂苷 S3()和人参皂苷 S4()，以及一种已知化合物。当 A549 细胞暴露于香烟烟雾（CS）提取物时，人参皂苷 S2 显著减轻了氧化损伤。此外，人参皂苷 S2 可以抑制 CS 诱导的 A549 细胞炎症反应。人参皂苷 S2 对 CS 介导的 A549 细胞氧化应激和炎症反应的保护作用可能涉及 Nrf2 和 HDAC2 通路。
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