Wu Xuejie, Chen Donglai, Zhu Rongying, Wang Yifei, Chen Chang, Chen Yongbing, Yang Wentao
Department of Thoracic Surgery, the Second Affiliated Hospital of Soochow University, Suzhou 215000, China.
Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.
Zhongguo Fei Ai Za Zhi. 2019 Mar 20;22(3):173-177. doi: 10.3779/j.issn.1009-3419.2019.03.10.
Lung cancer leads to the highest cancer-related morbidity and mortality worldwide. With the development of multi-slice spiral computed tomography technology and the implement of lung cancer screening, more and more lung nodules have been discovered, many of which are multiple pulmonary nodules. These pulmonary nodules are usually diagnosed as multiple primary lung adenocarcinomas from a pathological perspective. For multiple nodules with different imaging features, the preferred treatment methods are different, and the treatment of each lung nodule is still controversial. In recent years, the interactions between multiple lesions and the evolution of the lesions as well as the inter-tumoral and intratumoral homogeneity and heterogeneity of the genomics also arouse attention. Our review gathered the research progress in multiple pulmonary nodules from the points of histopathology, genomics and surgical management. .
肺癌导致全球范围内与癌症相关的最高发病率和死亡率。随着多层螺旋计算机断层扫描技术的发展以及肺癌筛查的实施，越来越多的肺结节被发现，其中许多是多发性肺结节。从病理学角度来看，这些肺结节通常被诊断为多发性原发性肺腺癌。对于具有不同影像学特征的多个结节，首选的治疗方法不同，并且每个肺结节的治疗仍存在争议。近年来，多个病灶之间的相互作用、病灶的演变以及基因组学的肿瘤间和肿瘤内的同质性和异质性也引起了关注。我们的综述从组织病理学、基因组学和外科治疗管理等方面收集了多发性肺结节的研究进展。
