Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada; Department of Plant, Food, and Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, NS, Canada.
Cancer Lett. 2019 Jun 28;452:168-177. doi: 10.1016/j.canlet.2019.03.022. Epub 2019 Mar 22.
Many advances have been made in the development and introduction of new anti-cancer drugs to the clinic. However, limited attention has been paid to improving the efficacy of currently available treatments through complementary phytochemical interventions that affect cellular reactive oxygen species (ROS) levels, which are important for the etiology of certain cancers and the effectiveness of radiotherapy and some chemotherapy. In this regard, the maintenance of redox homeostasis may be influenced by the intake of anti-oxidant and pro-oxidant compounds from dietary sources. Interestingly, certain dietary phytochemicals exhibit both anti-oxidant and pro-oxidant activities, depending on their concentration and cellular microenvironment. There is evidence that concurrent administration of some dietary phytochemicals enhances the efficacy of certain cancer treatments by increasing intracellular ROS accumulation. Paradoxically, consumption of the same dietary phytochemicals under conditions that result in the scavenging of ROS might also negatively affect the outcome of ROS-dependent cancer treatments. This review discusses the potential impact of consuming dietary phytochemicals with anti-oxidant and/or pro-oxidant activities on the effectiveness of concurrent chemotherapy and/or radiotherapy in cancer patients.
许多新的抗癌药物在开发和引入临床方面都取得了进展。然而，人们很少关注通过补充植物化学干预来提高现有治疗方法的疗效，这些干预措施会影响细胞内的活性氧（ROS）水平，而 ROS 水平对某些癌症的病因和放射治疗以及某些化疗的有效性都很重要。在这方面，通过摄入来自饮食来源的抗氧化和促氧化剂化合物，可能会影响氧化还原平衡的维持。有趣的是，某些膳食植物化学物质根据其浓度和细胞微环境表现出抗氧化和促氧化活性。有证据表明，某些膳食植物化学物质的同时给药通过增加细胞内 ROS 积累来提高某些癌症治疗的疗效。矛盾的是，在导致 ROS 清除的情况下消耗相同的膳食植物化学物质也可能对 ROS 依赖性癌症治疗的结果产生负面影响。本文讨论了具有抗氧化和/或促氧化活性的膳食植物化学物质的消耗对癌症患者同时进行化疗和/或放疗的有效性的潜在影响。
