Lim Heui Min, Park See-Hyoung
Department of Biological Science, Gachon University, Seongnam, Republic of Korea.
Department of Bio and Chemical Engineering, Hongik University, Sejong, Republic of Korea.
Crit Rev Food Sci Nutr. 2023;63(22):5911-5936. doi: 10.1080/10408398.2022.2025574. Epub 2022 Jan 7.
Cancer and diabetes mellitus are served as typical life-threatening diseases with common risk factors. Developing therapeutic measures in cancers and diabetes have aroused attention for a long time. However, the problems with conventional treatments are in challenge, including side effects, economic burdens, and patient compliance. It is essential to secure safe and efficient therapeutic methods to overcome these issues. As an alternative method, antioxidant and pro-oxidant properties of phytochemicals from edible plants have come to the fore. Phytochemicals are naturally occurring compounds, considered promising agent applicable in treatment of various diseases with beneficial effects. Either antioxidative or pro-oxidative activity of various phytochemicals were found to contribute to regulation of cell proliferation, differentiation, cell cycle arrest, and apoptosis, which can exert preventive and therapeutic effects against cancer and diabetes. In this article, the antioxidant or pro-oxidant effects and underlying mechanisms of flavonoids, alkaloids, and saponins in cancer or diabetic models demonstrated by the recent studies are summarized.
癌症和糖尿病是具有常见风险因素的典型危及生命的疾病。开发针对癌症和糖尿病的治疗措施长期以来一直备受关注。然而，传统治疗方法存在诸多问题，包括副作用、经济负担和患者依从性等方面面临挑战。确保安全有效的治疗方法以克服这些问题至关重要。作为一种替代方法，可食用植物中植物化学物质的抗氧化和促氧化特性已受到关注。植物化学物质是天然存在的化合物，被认为是适用于治疗各种疾病且具有有益作用的有前景的药物。已发现各种植物化学物质的抗氧化或促氧化活性有助于调节细胞增殖、分化、细胞周期停滞和凋亡，从而对癌症和糖尿病发挥预防和治疗作用。在本文中，总结了近期研究在癌症或糖尿病模型中所证实的黄酮类化合物、生物碱和皂苷的抗氧化或促氧化作用及其潜在机制。
