铱催化苯甲酸与三氟甲基化炔烃环化反应区域选择性合成三氟甲基化异香豆素
Iridium-Catalyzed Regioselective Synthesis of Trifluoromethylated Isocoumarins through Annulation of Benzoic Acids with Trifluoromethylated Alkynes.
作者信息
Liu Guangyuan, Kuang Guanghua, Zhang Xingxing, Lu Naihao, Fu Yang, Peng Yiyuan, Zhou Yirong
机构信息
Key Laboratory of Fuctional Small Organic Molecule, Ministry of Education, College of Chemistry and Chemical Engineering , Jiangxi Normal University , No. 99 Ziyang Road , Nanchang 330022 , China.
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College , Huazhong University of Science and Technology , No. 13 Hangkong Road , Wuhan 430030 , China.
出版信息
Org Lett. 2019 May 3;21(9):3043-3047. doi: 10.1021/acs.orglett.9b00572. Epub 2019 Mar 26.
An unprecedented Ir-catalyzed oxidative coupling of benzoic acids with trifluoromethylated alkynes was successfully developed to provide diverse trifluoromethylated isocoumarins in moderate to good yields. This new practical procedure was highlighted by mild reaction conditions, broad substrate scope, good regioselectivity, high efficiency, and easy operation.
成功开发了一种前所未有的铱催化苯甲酸与三氟甲基化炔烃的氧化偶联反应，以中等至良好的产率提供各种三氟甲基化异香豆素。该新的实用方法具有反应条件温和、底物范围广、区域选择性好、效率高和操作简便等特点。
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