衰老细胞在心脏代谢疾病中的作用。
Senescent cells in the development of cardiometabolic disease.
机构信息
Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Departments of Pediatrics and Adolescent Medicine.
出版信息
Curr Opin Lipidol. 2019 Jun;30(3):177-185. doi: 10.1097/MOL.0000000000000602.
PURPOSE OF REVIEW
Senescent cells have recently been identified as key players in the development of metabolic dysfunction. In this review, we will highlight recent developments in this field and discuss the concept of targeting these cells to prevent or treat cardiometabolic diseases.
RECENT FINDINGS
Evidence is accumulating that cellular senescence contributes to adipose tissue dysfunction, presumably through induction of low-grade inflammation and inhibition of adipogenic differentiation leading to insulin resistance and dyslipidaemia. Senescent cells modulate their surroundings through their bioactive secretome and only a relatively small number of senescent cells is sufficient to cause persistent physical dysfunction even in young mice. Proof-of-principle studies showed that selective elimination of senescent cells can prevent or delay the development of cardiometabolic diseases in mice.
SUMMARY
The metabolic consequences of senescent cell accumulation in various tissues are now unravelling and point to new therapeutic opportunities for the treatment of cardiometabolic diseases.
目的综述
衰老细胞最近被确定为代谢功能障碍发展的关键因素。在这篇综述中，我们将强调该领域的最新进展，并讨论针对这些细胞以预防或治疗心脏代谢疾病的概念。
最近的发现
越来越多的证据表明，细胞衰老导致脂肪组织功能障碍，可能是通过诱导低度炎症和抑制脂肪生成分化导致胰岛素抵抗和血脂异常。衰老细胞通过其生物活性分泌组来调节其周围环境，即使在年轻小鼠中，相对较少数量的衰老细胞也足以导致持续的身体功能障碍。原理验证研究表明，选择性消除衰老细胞可以预防或延迟小鼠心脏代谢疾病的发展。
总结
各种组织中衰老细胞积累的代谢后果正在被揭示，并为治疗心脏代谢疾病提供了新的治疗机会。
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