果蝇hsp23基因的热休克和蜕皮激素激活；一个与发育调控相关的序列元件
Heat shock and ecdysterone activation of the Drosophila melanogaster hsp23 gene; a sequence element implied in developmental regulation.
作者信息
Mestril R, Schiller P, Amin J, Klapper H, Ananthan J, Voellmy R
出版信息
EMBO J. 1986 Jul;5(7):1667-73. doi: 10.1002/j.1460-2075.1986.tb04410.x.
Abstract
The regulation of the Drosophila melanogaster hsp23 gene by heat shock and ecdysterone has been analysed by measuring activities of hsp--Escherichia coli beta-galactosidase hybrid genes in transfected hormone-sensitive D. melanogaster cells. Mutation analysis identified multiple, distinct promoter elements. A sequence element, which also occurs in the promoters of several other developmentally regulated Drosophila genes, is present in regions of the hsp23 promoter that are essential for its ecdysterone, but not its heat-regulated activity; this element may represent a binding site for an ecdysterone--receptor complex. Mutant promoters that can be activated only by heat shock or by hormone have been constructed. Thus the two types of regulation of the hsp23 gene can function independently of each other.
摘要
通过测量转染了激素敏感型黑腹果蝇细胞中hsp - 大肠杆菌β - 半乳糖苷酶杂交基因的活性，对黑腹果蝇hsp23基因受热休克和蜕皮激素的调控进行了分析。突变分析确定了多个不同的启动子元件。一种也存在于其他几个发育调控的果蝇基因启动子中的序列元件，位于hsp23启动子对其蜕皮激素（而非热调节活性）至关重要的区域；该元件可能代表蜕皮激素 - 受体复合物的结合位点。已经构建了仅能受热休克或激素激活的突变启动子。因此，hsp23基因的两种调控类型可以相互独立发挥作用。
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