School of Electronic Science and Engineering (National Exemplary School of Microelectronics), University of Electronic Science and Technology of China, Chengdu, China.
Center for Information in Medicine, University of Electronic and Technology of China, Chengdu, China.
J Biophotonics. 2019 Jun;12(6):e201900004. doi: 10.1002/jbio.201900004. Epub 2019 Apr 10.
Monitoring the blood supply in the lower extremities is critical for individuals who are vulnerable to vascular dysfunction. Current clinical approaches are ineffective in observing hemodynamic changes in peripheral vessels. In this paper, we investigate the potential of photoacoustic tomography (PAT) as an alternative way to in vivo monitor hemodynamic changes in foot vessels. High spatial and temporal resolution maps of hemoglobin in major arteries and veins are shown. Results from twelve human subjects are presented here to visualize vascular perfusion of healthy volunteers in two age groups (young vs aged). Significant differences between the two groups are observed and verify the declining in vascular function with aging, highlighting the potential of PAT as a new tool to evaluate vascular function in the lower extremities.
监测下肢的血液供应对于易发生血管功能障碍的个体至关重要。目前的临床方法无法观察到外周血管的血液动力学变化。在本文中，我们研究了光声断层扫描（PAT）作为一种替代方法来活体监测足部血管血液动力学变化的潜力。显示了主要动脉和静脉中血红蛋白的高空间和时间分辨率图谱。这里呈现了来自 12 名人类受试者的结果，以可视化两个年龄组（年轻组与老年组）健康志愿者的血管灌注情况。观察到两组之间的显著差异，证实了血管功能随年龄的衰退，突显了 PAT 作为评估下肢血管功能的新工具的潜力。
