Naing Cho, Htet Norah Htet, Basavaraj Arun Kumar, Nalliah Sivalingam
1Institute for Research, Development and Innovation (IRDI), International Medical University, Kuala Lumpur, Malaysia.
2Division of Tropical Health and Medicine, James Cook University, Townsville, Queensland Australia.
J Diabetes Metab Disord. 2018 Sep 1;17(2):333-343. doi: 10.1007/s40200-018-0349-3. eCollection 2018 Dec.
This study aimed to synthesize evidence on the association between IL-10 gene (-819 C/T, -1082 A/G, -592 A/C) polymorphisms and the risk of developing diabetic nephropathy.
A systematic literature search was done in health-related electronic databases. The search was limited to studies published in English until September 2017. We also checked the references of retrieved articles and relevant reviews for any additional studies. The methodological quality of the studies included in this review was assessed using the 'Scales for Quality Assessment'. The test was used to quantify between-study heterogeneity. A value of > 50% indicated substantial heterogeneity. For the pooled analysis, summary odds ratio (OR) and its 95% confidence interval (CI) in random effect model were used.
Eight case-control studies (1192 cases with diabetic nephropathy and 2399 controls) met the inclusion criteria. Three groups of people namely Africans, Asians and Caucasians were included in this review. There were significant protective effects of SNP -819 C/T in overall population (OR 0.32, 95% CI 0.26-0.4) and - 1082 A/G SNP in the Asian population (OR 0.64, 95% CI 0.47-0.86) on diabetic nephropathy in the recessive model. There was no significant effect of -592 A/C on diabetic nephropathy.
The findings suggest the protective effects of -1082A/G and -819G/A polymorphisms on the risk of developing diabetic nephropathy in type 2 diabetes mellitus, especially in the Asian population. Well- designed, prospective studies with sufficient number of participants are recommended to substantiate these findings.
本研究旨在综合关于白细胞介素-10基因（-819 C/T、-1082 A/G、-592 A/C）多态性与糖尿病肾病发生风险之间关联的证据。
在与健康相关的电子数据库中进行了系统的文献检索。检索仅限于截至2017年9月以英文发表的研究。我们还检查了检索到的文章的参考文献以及相关综述，以寻找任何其他研究。使用“质量评估量表”评估本综述中纳入研究的方法学质量。采用I²检验来量化研究间的异质性。I²值>50%表明存在实质性异质性。对于汇总分析，使用随机效应模型中的汇总比值比（OR）及其95%置信区间（CI）。
八项病例对照研究（1192例糖尿病肾病患者和2399例对照）符合纳入标准。本综述纳入了非洲人、亚洲人和高加索人三组人群。在隐性模型中，SNP -819 C/T在总体人群中（OR 0.32，95% CI 0.26 - 0.4）以及-1082 A/G SNP在亚洲人群中（OR 0.64，95% CI 0.47 - 0.86）对糖尿病肾病有显著的保护作用。-592 A/C对糖尿病肾病没有显著影响。
研究结果表明-1082A/G和-819G/A多态性对2型糖尿病患者发生糖尿病肾病的风险具有保护作用，尤其是在亚洲人群中。建议进行设计良好、有足够数量参与者的前瞻性研究来证实这些发现。
