针对微生物的抗原受体携带 B 细胞作为疫苗发现和设计的工具。
B Cells Carrying Antigen Receptors Against Microbes as Tools for Vaccine Discovery and Design.
机构信息
Department of Immunology and Microbiology, The Scripps Research Institute, 10550 North Torrey Pines Rd, IM29, La Jolla, CA, 92037, USA.
出版信息
Curr Top Microbiol Immunol. 2020;428:165-180. doi: 10.1007/82_2019_156.
Abstract
Can basic science improve the art of vaccinology? Here, we review efforts to understand immune responses with the aim to improve vaccine design and, eventually, to predict the efficacy of human vaccine candidates using the tools of transformed B cells and targeted transgenic mice carrying B cells with antigen receptors specific for microbes of interest.
摘要
基础科学能否提高疫苗学的水平？在这里，我们回顾了用旨在改进疫苗设计的方法来理解免疫应答的努力，最终，我们使用经过转化的 B 细胞工具以及携带针对感兴趣微生物的抗原受体的靶向转基因小鼠来预测人类候选疫苗的疗效。
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