Department of Process & Chemical Engineering, University College Cork, Ireland.
Department of Process & Chemical Engineering, University College Cork, Ireland.
Biotechnol Adv. 2019 Sep-Oct;37(5):698-707. doi: 10.1016/j.biotechadv.2019.03.015. Epub 2019 Mar 26.
Biopharmaceuticals manufacturing is a critical component of the modern healthcare system, with emerging new treatments composed of increasingly complex biomolecules offering solutions to chronic and debilitating disorders. While this sector continues to grow, it strongly exhibits "boom-to-bust" performance which threatens its long-term viability. Future trends within the industry indicate a shift towards continuous production systems using single use technologies that raises sustainability issues, yet research in this area is sparse and lacks consideration of the complex interactions between environmental, social and economic concerns. The authors outline a sustainability-focused vision and propose opportunities for research to aid the development of a more integrated approach that would enhance the sustainability of the industry.
生物制药制造是现代医疗保健系统的关键组成部分，新兴的新治疗方法由越来越复杂的生物分子组成，为慢性和衰弱性疾病提供了解决方案。虽然该行业持续增长，但它表现出强烈的“繁荣-萧条”性能，这威胁到其长期生存能力。该行业的未来趋势表明，将转向使用一次性技术的连续生产系统，这引发了可持续性问题，但该领域的研究很少，并且没有考虑到环境、社会和经济问题之间的复杂相互作用。作者概述了一个以可持续性为重点的愿景，并提出了研究机会，以帮助开发更具综合性的方法，从而提高该行业的可持续性。
