Gustavson Daniel E, Franz Carol E, Panizzon Matthew S, Reynolds Chandra A, Xian Hong, Jacobson Kristen C, Toomey Rosemary, Lyons Michael J, Kremen William S
Department of Psychiatry, Center for Behavior Genetics of Aging, University of California, San Diego.
Department of Psychology, University of California, Riverside.
Clin Psychol Sci. 2019 Jan;7(1):127-142. doi: 10.1177/2167702618805075. Epub 2018 Nov 13.
Multiple executive functions (EFs) are associated with trait anxiety and depression symptoms, but it is unclear how genetic and/or environmental factors account for these associations, and if they are explained by general variance underlying multiple EFs (i.e., Common EF). In this study, 1207 male twins completed seven EF tasks and measures of trait anxiety and depression symptoms at average age 62. The Common EF factor was associated with both anxiety (= -.25) and depression symptoms (= -.35). Anxiety and depression had near complete genetic overlap ( =.96). Genetic influences shared with depression accounted for 83% of the phenotypic correlation between anxiety and Common EF. For depression, the phenotypic correlation with Common EF was explained by genetic influences shared with anxiety (69%), but also nonshared environmental influences distinct from anxiety (20%). These results suggest that genetic influences on Common EF play a role in the observed genetic overlap between anxiety and depression.
多种执行功能（EFs）与特质焦虑和抑郁症状相关，但尚不清楚遗传和/或环境因素如何解释这些关联，以及它们是否由多种执行功能（即共同执行功能）背后的一般方差来解释。在本研究中，1207名男性双胞胎在平均年龄62岁时完成了七项执行功能任务以及特质焦虑和抑郁症状的测量。共同执行功能因素与焦虑（=-0.25）和抑郁症状（=-0.35）均相关。焦虑和抑郁具有近乎完全的遗传重叠（=0.96）。与抑郁共享的遗传影响占焦虑与共同执行功能之间表型相关性的83%。对于抑郁，与共同执行功能的表型相关性由与焦虑共享的遗传影响（69%）以及与焦虑不同的非共享环境影响（20%）来解释。这些结果表明，对共同执行功能的遗传影响在焦虑和抑郁之间观察到的遗传重叠中起作用。
