Rummens J L, Verfaillie C, Criel A, Hidajat M, Vanhoof A, Van den Berghe H, Louwagie A
Acta Haematol. 1986;75(3):174-7. doi: 10.1159/000206114.
Marked elliptocytosis and schistocytosis are described as unusual manifestations of haematopoietic dysplasia in two patients. The first patient, whose history was negative for inherited haemolytic anaemias, presented these prominent features on his first admission; 22 months later he developed an acute myeloblastic leukaemia. In the second patient, followed since 4 years for an autoimmune thrombocytopenic purpura, elliptocytosis and schistocytosis appeared 17 months before a pancytopenia established. The patient is now on follow-up and is treated for a refractory anaemia. In both cases bone marrow examinations revealed the typical criteria for myelodysplasia and this diagnosis was confirmed by cytogenetic analysis.
两名患者出现显著的椭圆形红细胞增多症和裂红细胞症，被描述为造血发育异常的不寻常表现。首例患者既往无遗传性溶血性贫血病史，首次入院时即表现出这些显著特征；22个月后，他发展为急性髓细胞白血病。第二例患者因自身免疫性血小板减少性紫癜已随访4年，椭圆形红细胞增多症和裂红细胞症在全血细胞减少症出现前17个月出现。该患者目前正在接受随访，并因难治性贫血接受治疗。在这两例病例中，骨髓检查均显示出骨髓发育异常的典型标准，细胞遗传学分析证实了这一诊断。
