Inserm, U1028; CNRS, UMR5292, Lyon Neuroscience Research Center, Psychiatric Disorders: from Resistance to Response Team, 69000 Lyon, France; University Lyon 1, 69000 Villeurbanne, France; Centre hospitalier Le Vinatier, bâtiment 416, 95, boulevard Pinel, BP 300 39, 69678 Bron cedex, France.
Inserm, U1028; CNRS, UMR5292, Lyon Neuroscience Research Center, Psychiatric Disorders: from Resistance to Response Team, 69000 Lyon, France; University Lyon 1, 69000 Villeurbanne, France; Department of Psychiatry, University Hospital Lyon Sud, Hospices civils de Lyon, 69000 Lyon, France.
Neurophysiol Clin. 2019 Jun;49(3):243-248. doi: 10.1016/j.neucli.2019.03.002. Epub 2019 Mar 28.
The Stroop effect performance reflects cognitive resistance to interference. We aimed to investigate the effect of a single transcranial random noise stimulation session (tRNS) applied over the dorsolateral prefrontal cortex (DLPFC) on the semantic Stroop effect and its resting electroencephalography (EEG) correlates (β/α ratio).
In a randomized, double-blind study, healthy volunteers were allocated to receive either one session of active tRNS (n=8) or one session of sham tRNS (n=11). The anode pad was placed on the scalp over the right-DLPFC and the cathode pad was placed over the left-DLPFC. A computerized adaptation of the French Stroop Color-Word Test (Victoria version) and a resting-state continuous EEG recording were administered before and after the tRNS.
No significant difference were observed for either Stroop Interference/Congruent (F=0.5, P=.5, BF=.19) or Interference/Cross (F=3.2, P=.1, BF=0.25) ratios. No significant effect of tRNS was observed on EEG β/α ratios across electrodes (F=0.6, P=.7, BF=0.59e). Under active stimulation, Pearson's tests showed significant correlations with moderate evidence between post-pre differences of Stroop Interference/Congruent and Fz-β/α ratios (r=0.88, P=.02, BF=4.05), and Stroop Interference/Crosses and Cz-β/α ratios (r=0.89, P=.008, BF=8.25), while the same correlations did not reach significance under sham conditions.
We observed no significant changes in either semantic Stroop task reaction time or its EEG correlates after tRNS. However, we provide the original finding that fronto-central β/α activity becomes related to cognitive resistance to interference when the DLPFC is stimulated with random noise current. The results suggest a potential resynchronization of relevant brain frequency patterns into Stroop-related cortical involvement.
斯特鲁普效应表现反映了认知对干扰的抵抗。我们旨在研究单次经颅随机噪声刺激（tRNS）应用于背外侧前额叶皮层（DLPFC）对语义斯特鲁普效应及其静息脑电图（EEG）相关性（β/α 比）的影响。
在一项随机、双盲研究中，健康志愿者被分配接受一次真 tRNS（n=8）或一次假 tRNS（n=11）治疗。阳极片置于右 DLPFC 头皮上，阴极片置于左 DLPFC 头皮上。在 tRNS 前后进行了计算机化的法语斯特鲁普颜色-词测试（维多利亚版本）和静息状态连续 EEG 记录。
无论是斯特鲁普干扰/一致（F=0.5，P=.5，BF=.19）还是干扰/交叉（F=3.2，P=.1，BF=0.25）比值，都没有观察到 tRNS 的显著差异。tRNS 对电极之间的 EEGβ/α 比值没有显著影响（F=0.6，P=.7，BF=0.59e）。在主动刺激下，皮尔逊检验显示，斯特鲁普干扰/一致的前后差异与 Fz-β/α 比值（r=0.88，P=.02，BF=4.05）之间存在显著相关，且具有中等证据水平；斯特鲁普干扰/交叉与 Cz-β/α 比值（r=0.89，P=.008，BF=8.25）之间存在显著相关，而在假刺激条件下，这些相关性没有达到显著水平。
我们没有观察到 tRNS 后语义斯特鲁普任务反应时间或其 EEG 相关性的显著变化。然而，我们提供了一个原始发现，即在 DLPFC 受到随机噪声电流刺激时，额中央β/α 活动与认知对干扰的抵抗有关。结果表明，相关脑频率模式可能重新同步到与斯特鲁普相关的皮质参与中。
