非小细胞肺癌伴脑转移患者的血小板指标。

Platelet indices in non-small cell lung cancer patients with brain metastases.

机构信息

Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, China.

Institute of Intensive Care Unit, Heilongjiang Academy of Medical Science, Harbin, Heilongjiang 150081, China.

出版信息

Cancer Biomark. 2019;24(4):515-519. doi: 10.3233/CBM-192393.

DOI:10.3233/CBM-192393

PMID:30932885

Abstract

BACKGROUND

Platelets play a crucial role in cancer progression and metastasis. The aim of the present study was to assess the relationship between platelet indices and non-small cell lung cancer (NSCLC) with brain metastases.

METHODS

Between January 2015 and December 2017, 232 NSCLC patients with brain metastases and 244 NSCLC patients without metastases were retrospectively analyzed. Patients' clinicopathological characteristics data were collected.

RESULTS

Platelet count was increased and mean platelet volume (MPV) was reduced in NSCLC patients with brain metastases compared with NSCLC patients without metastases. In addition, the prevalence of NSCLC decreased as MPV quartiles increased. After adjusting for other risk factors, the ORs (95% CIs) for NSCLC brain metastases according to MPV quartiles were 1.757 (1.024-3.015), 2.097 (1.209-3.635), 1.517 (0.874-2.635), and 1.000, respectively.

CONCLUSIONS

MPV is reduced in NSCLC patients with brain metastases compared with NSCLC patients without metastases. Moreover, MPV is found to be independently associated with the presence of NSCLC brain metastases.

摘要

背景

血小板在癌症的进展和转移中起着至关重要的作用。本研究旨在评估血小板指数与非小细胞肺癌（NSCLC）伴脑转移之间的关系。

方法

回顾性分析了 2015 年 1 月至 2017 年 12 月期间 232 例伴脑转移的 NSCLC 患者和 244 例无转移的 NSCLC 患者。收集了患者的临床病理特征数据。

结果

与无脑转移的 NSCLC 患者相比，伴脑转移的 NSCLC 患者的血小板计数增加，平均血小板体积（MPV）降低。此外，随着 MPV 四分位的升高，NSCLC 的患病率降低。在校正其他危险因素后，MPV 四分位的 NSCLC 脑转移的 OR（95%CI）分别为 1.757（1.024-3.015）、2.097（1.209-3.635）、1.517（0.874-2.635）和 1.000。