Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.
Can J Physiol Pharmacol. 2019 Aug;97(8):721-728. doi: 10.1139/cjpp-2018-0620. Epub 2019 Apr 1.
The current study evaluated whether fructose supplementation affects oxidative stress and metabolic parameters in the liver and gastrocnemius muscle of rats subjected to swimming exercise. Male adult Wistar rats received a fructose solution (10%) or water during 1 h before exercise and during the rest interval by the intragastric route. The swimming protocol consisted of 6 days: each day, rats underwent 3 sessions of 17 min each, with a load of 5% of body mass, and rest intervals of 3 min. Fructose supplementation changed metabolic and oxidative parameters in the liver and gastrocnemius muscle of sedentary rats. Swimming exercise counteracted the increase of triglyceride levels in plasma and liver induced by fructose supplementation. It also reduced thiobarbituric acid reactive species levels in the liver, and catalase and superoxide dismutase activities in the gastrocnemius muscle of supplemented rats. However, fructose supplementation worsened metabolic (hepatic triglyceride levels) and oxidative parameters (thiobarbituric acid reactive species levels) in the liver and gastrocnemius of exercised rats. This study demonstrates that oxidative stress and metabolic parameters were differently affected by fructose supplementation when rats were kept sedentary or underwent swimming exercise. The present results indicate the need of a new insight of the role of fructose supplementation during physical exercise.
本研究旨在评估补充果糖是否会影响游泳运动后大鼠肝脏和比目鱼肌的氧化应激和代谢参数。雄性成年 Wistar 大鼠在运动前 1 小时和休息期间通过胃内途径给予果糖溶液（10%）或水。游泳方案包括 6 天：每天，大鼠进行 3 次 17 分钟的游泳，负荷为体重的 5%，休息时间为 3 分钟。果糖补充改变了安静大鼠肝脏和比目鱼肌的代谢和氧化参数。游泳运动还降低了果糖补充引起的血浆和肝脏中甘油三酯水平的升高。它还降低了补充大鼠肝脏中丙二醛反应性物质的水平以及比目鱼肌中的过氧化氢酶和超氧化物歧化酶的活性。然而，果糖补充加重了运动大鼠肝脏和比目鱼肌的代谢（肝甘油三酯水平）和氧化参数（丙二醛反应性物质水平）。本研究表明，当大鼠保持安静或进行游泳运动时，果糖补充对氧化应激和代谢参数的影响不同。本研究结果表明，在运动期间需要对果糖补充的作用有新的认识。
