1 Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, USA.
2 Department of Otolaryngology, Massachusetts Eye and Ear, Boston, Massachusetts, USA.
Otolaryngol Head Neck Surg. 2019 Jun;160(6):965-973. doi: 10.1177/0194599819838782. Epub 2019 Apr 2.
To provide a comprehensive overview of the emerging role of periostin, an extracellular matrix protein, as a key component in the development, diagnosis, and treatment of patients with chronic rhinosinusitis.
Medline database.
A state of the art review was performed targeting English-language studies investigating the role of periostin in cardiopulmonary, neoplastic, and inflammatory diseases, with emphasis on recent advances in the study of periostin in chronic rhinosinusitis.
Periostin has emerged as a novel biomarker and therapeutic target for numerous human pathologies, including cardiac, pulmonary, and neoplastic disease. The upregulation of periostin in chronic rhinosinusitis suggests the potential for similar roles among patients with sinonasal disease.
Chronic rhinosinusitis is a widespread disease with major clinical and societal impact. A critical limitation in the current treatment of patients with chronic rhinosinusitis is the absence of clinically relevant biomarkers to guide diagnosis and treatment selection. A review of the literature supports a likely role of periostin as a biomarker of chronic rhinosinusitis, as well as a novel therapeutic target in the future treatment of patients with sinonasal disease.
全面概述细胞外基质蛋白骨膜蛋白在慢性鼻-鼻窦炎患者的发展、诊断和治疗中的作用。
Medline 数据库。
针对探讨骨膜蛋白在心肺、肿瘤和炎症性疾病中作用的英文文献进行了一项现状综述，重点介绍了骨膜蛋白在慢性鼻-鼻窦炎研究中的最新进展。
骨膜蛋白已成为多种人类病理的新型生物标志物和治疗靶点，包括心脏、肺部和肿瘤疾病。慢性鼻-鼻窦炎中骨膜蛋白的上调表明其在鼻-鼻窦疾病患者中可能具有相似作用。
慢性鼻-鼻窦炎是一种广泛存在的疾病，对临床和社会都有重大影响。目前对慢性鼻-鼻窦炎患者的治疗存在一个关键的局限性，即缺乏用于指导诊断和治疗选择的临床相关生物标志物。文献综述支持骨膜蛋白作为慢性鼻-鼻窦炎的生物标志物，以及未来鼻-鼻窦疾病患者治疗的新型治疗靶点的可能性。
