Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Complement Ther Med. 2019 Apr;43:181-187. doi: 10.1016/j.ctim.2019.01.022. Epub 2019 Jan 23.
A number of studies have examined the beneficial effects of Coenzyme Q10 (CoQ10) on fatigue in different population, but the findings have been inconclusive. Herein, we systematically reviewed available interventional studies to elucidate the overall effects of CoQ10 supplementation on fatigue among adolescent and adult population.
PubMed, Cochrane's library, Science direct, Scopus, Google scholar and ISI web of science databases were searched for all available literature until April 2018 for studies assessing the effects of CoQ10 supplementation on fatigue. The Cochrane bias assessment tool were used to assess the quality of studies.
A total of 16 studies out of 1316 met our inclusion criteria and included in our systematic review. Among included studies 10 of them showed significant beneficial effects (p < 0.05) of CoQ10 supplementation on fatigue status among healthy, fibromyalgia, statin-related fatigue, multiple sclerosis and end-stage heart failure subjects. CoQ10 supplementation could alleviate fatigue, but differences between studies population should be taken into account.
It seems CoQ10 has better therapeutic effects in statin-related fatigue and fibromyalgia patients compared with the other disease related fatigue. Finally, in order to draw a firm link between CoQ10 and fatigue, more clinical trials with adequate sample size and with sufficient follow-up periods are needed.
许多研究已经研究了辅酶 Q10（CoQ10）对不同人群疲劳的有益影响，但结果尚无定论。在此，我们系统地回顾了现有干预性研究，以阐明 CoQ10 补充剂对青少年和成年人群疲劳的总体影响。
我们检索了 PubMed、Cochrane 图书馆、Science direct、Scopus、Google scholar 和 ISI web of science 数据库，以获取截至 2018 年 4 月评估 CoQ10 补充剂对疲劳影响的所有可用文献。使用 Cochrane 偏倚评估工具评估研究质量。
在 1316 篇文献中，共有 16 篇符合我们的纳入标准，并纳入了我们的系统评价。在纳入的研究中，有 10 项研究表明 CoQ10 补充剂对健康、纤维肌痛、他汀类药物相关疲劳、多发性硬化症和终末期心力衰竭患者的疲劳状况有显著的有益影响（p<0.05）。CoQ10 补充剂可以缓解疲劳，但应考虑到研究人群之间的差异。
CoQ10 似乎在他汀类药物相关疲劳和纤维肌痛患者中比其他疾病相关疲劳患者具有更好的治疗效果。最后，为了在 CoQ10 和疲劳之间建立更紧密的联系，需要进行更多具有足够样本量和足够随访期的临床试验。
